Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style XBF3)

In this review the Brooks Womens Glycerin 22 stands out as a plush, neutral running shoe best suited to runners and active women who prioritize maximum cushioning without sacrificing a responsive toe-off. The single biggest reason to consider the Glycerin 22 is its DNA Tuned midsole, which blends larger heel cells for soft landings with smaller forefoot cells for energetic transitions, creating notably smooth stride-to-stride feel while also meeting the needs of customers seeking roomy toes and reliable heel padding.

Key Features

• Neutral Support: Provides neutral guidance with the maximum amount of cushioning, making it comfortable for road running, cross training and gym sessions.
• DNA Tuned Cushion: Larger midsole cells in the heel deliver soft, plush landings while smaller forefoot cells create a more responsive toe-off for smoother transitions.
• Accommodating Fit: The double jacquard knit upper offers a flexible, breathable fit that adapts to foot shape while remaining durable over time.
• Smooth, Stable Transitions: A broad platform combined with tuned heel and forefoot geometry stabilizes the foot and smooths heel-to-toe motion.
• Medical and Podiatric Acceptance: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance, reassuring buyers who need extra foot health credentials.

Who It's For

The Glycerin 22 is ideal for women who want a soft, cushioned ride for road miles, longer recovery runs, or everyday training and gym work where comfort is the priority. Its neutral platform will suit runners with normal pronation who seek maximum cushioning and a roomy toe box.

Runners who need firm stability or heavy corrective support should look at the Glycerin GTS 22 or stability models instead, since this version focuses on plush cushioning rather than motion control or aggressive arch correction.

Pros & Cons

Pros

• Exceptional cushioning that feels plush under foot for long runs and walking.
• Breathable, flexible double jacquard knit upper that accommodates different foot shapes.
• Stable broad platform and tuned midsole cells produce smooth heel-to-toe transitions.
• APMA Seal of Acceptance and PDAC A5500 diabetic certification for added foot health confidence.

Cons

• Some buyers note the price feels high compared with perceived value despite strong comfort.
• Neutral design may not provide enough support for runners who require corrective stability.

Specifications

Brand	Brooks
Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a top pick for women seeking plush cushioning and smooth transitions on the road or in the gym; its DNA Tuned midsole and accommodating knit upper make it comfortable for long wear, and the health certifications add confidence for sensitive feet. Buy it if you prioritize cushioning and a roomy fit, but choose a GTS or stability model if you need stronger motion control.

Frequently Asked Questions

Are these shoes good for long runs?
Yes, the Glycerin 22 offers maximal cushioning and smooth transitions that make it well suited to long road runs and recovery miles.

Do they provide arch support?
The shoe provides neutral support with cushioning; users report comfortable support but those needing strong corrective arch support should consider a stability model.

Are they breathable and roomy?
The double jacquard knit upper is breathable and accommodating, and customers commonly note ample toe room and a padded heel for comfort.