Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style XMW8)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is clear: this is a plush, neutral daily trainer best suited to runners and walkers who prioritize cushioning and smooth transitions. The Glycerin 22 stands out for its DNA Tuned midsole that blends larger heel cells with smaller forefoot cells to create soft landings and responsive toe-offs, and it also carries medical endorsements that matter for sensitive feet. If cushioning and a roomy, breathable fit are at the top of your list, this shoe delivers.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel and smaller ones in the forefoot create a balance of plush landings and energetic toe-offs for smoother strides.
• Neutral Support: Designed as a neutral shoe that provides the maximum amount of cushioning without added stability elements, ideal for natural gait patterns.
• Accommodating Fit: The double jacquard knit upper stretches and breathes to reduce pressure points while maintaining durability for regular use.
• Smooth Transitions: A broad platform plus tuned heel and forefoot work together to stabilize the foot and smooth heel-to-toe movement.
• Medical Endorsements: Certified PDAC A5500 as a diabetic shoe and awarded the APMA Seal of Acceptance, which can reassure buyers with foot health concerns.

Who It's For

The Glycerin 22 is best for neutral runners who want high levels of cushioning on road runs, long walks, gym sessions, or cross training where comfort and shock absorption matter. It also suits people who need an accommodating toe box and those who appreciate an upper that breathes during extended wear.

It is less appropriate for runners who need strong motion control or support for severe overpronation; those users should look at models with added stability features. Also, buyers who prefer a firm, minimalist ride may find the Glycerin 22 too soft for fast tempo runs.

Pros & Cons

Pros

• Exceptional cushioning that reduces impact and feels comfortable on long walks and runs.
• Breathable, flexible knit upper that accommodates a variety of foot shapes without feeling tight.
• Stable, broad platform and tuned midsole deliver smooth heel-to-toe transitions.
• Recognized medical certifications that support use by customers with sensitive feet.

Cons

• Sizing feedback is mixed from customers, so some may need to try a half size up or down to find the right fit.
• The very plush feel may feel too soft for faster runners who prefer a snappier ride.

Specifications

Model	Glycerin 22
Support	Neutral
Midsole Technology	DNA Tuned with dual-size midsole cells
Upper	Double jacquard knit for breathability and flexibility
Awards/Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for runners and walkers who prioritize cushioning, foot comfort and smooth transitions; its DNA Tuned midsole and wide platform make it especially good for longer road miles and everyday wear. Given its accommodating fit and medical endorsements, it represents good value for anyone seeking maximum plushness in a neutral trainer.

Frequently Asked Questions

Do these run true to size?
Customer reports are mixed, so try your usual size first but be prepared to exchange for a half size if the fit feels too small.

Are these good for long-distance road running?
Yes, the high level of cushioning and smooth transitions make them well suited to longer road runs and extended walking sessions.

Can people with sensitive feet use them?
Yes; the shoe is certified as a PDAC A5500 diabetic shoe and has the APMA Seal of Acceptance, making it a sensible option for sensitive feet.