Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style Y69V)

In this review of the Brooks Womens Glycerin 22 Neutral Running Shoe the bottom line is clear: this shoe is for runners and walkers who want maximum, plush cushioning with smooth transitions. The Glycerin 22 stands out for its DNA Tuned midsole that blends larger heel cells for soft landings with smaller forefoot cells for a responsive toe-off, making it ideal for long miles on the road and all-day comfort. It also carries the APMA Seal of Acceptance and is certified as a PDAC A5500 Diabetic shoe, which adds confidence for users who need foot health considerations.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide soft, plush landings while smaller forefoot cells improve responsiveness at toe-off for smoother runs.
• Neutral Support: Designed as a neutral shoe that delivers the maximum amount of cushioning without added stability posts, suitable for natural foot strike patterns.
• Accommodating Fit: The double jacquard knit upper gives a flexible, breathable fit that adapts to the foot while remaining durable for repeated use.
• Smooth Transitions: A broad platform combined with a tuned heel and forefoot stabilizes the foot and creates steady heel-to-toe motion.
• Health Certifications: Certified PDAC A5500 for diabetic footwear and granted the APMA Seal of Acceptance, offering reassurance for those prioritizing foot health.

Who It's For

The Glycerin 22 is best for neutral runners, road runners, and anyone who spends long periods on their feet and wants generous cushioning and a soft, protective ride. It also suits cross training and gym sessions where comfort and a stable platform are desirable.

Those who need strong corrective support for overpronation should look at stability alternatives such as the Glycerin GTS 22. Buyers seeking a very tight, performance race fit may also prefer a firmer, lower-profile trainer instead of this high-cushion model.

Pros & Cons

Pros

• Exceptional cushioning that reduces impact on knees and hips for long walks and runs.
• Comfortable, roomy toe box reported by users for less pressure on toes during extended wear.
• Accommodating knit upper that balances breathability with a secure feel.
• Recognized health credentials (PDAC A5500 and APMA) for added peace of mind.

Cons

• Sizing opinions vary and some customers find they run small, so careful sizing or trying on is recommended.
• The maximal cushioning may feel too soft for runners who prefer a firmer, more responsive race shoe.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Use	Road running, cross training, everyday wear
Health Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance

Our Verdict

The Brooks Womens Glycerin 22 is a strong choice for runners and walkers who prioritize plush cushioning, a stable platform, and foot-health credentials. It offers excellent long-distance comfort and versatile use across road runs and gym work, making it good value for anyone seeking maximum cushioning rather than a race-day, firm ride.

Frequently Asked Questions

Do these run true to size?
Customer reports vary and some find the fit small, so trying your normal size first or checking return options is wise.

Is this shoe suitable for overpronation?
No, the Glycerin 22 is a neutral shoe; runners needing added support should consider a stability model like the Glycerin GTS 22.

Can I use this shoe for walking long distances?
Yes, customers praise the cushioning and support for long walks and all-day comfort.