Brooks Womens Glycerin 22 Neutral Running Shoe - Plush (Style ZJDH)

Our review of the Brooks Womens Glycerin 22 finds it is a cushioning-first neutral running shoe best suited for road runners and anyone who prioritizes comfort and smooth transitions. The standout reason to buy is the updated DNA Tuned cushion, which blends larger heel cells and smaller forefoot cells to deliver soft landings without losing responsive toe-offs. It is also notable as a certified PDAC A5500 diabetic shoe with the APMA Seal of Acceptance, which underscores its comfort and foot-health focus.

Key Features

• DNA Tuned Cushion: Larger cells in the heel and smaller cells in the forefoot provide a combination of plush impact absorption and energetic toe-offs for smoother running.
• Neutral Support: The shoe offers a neutral platform with maximum cushioning, ideal for road running, gym sessions, and cross training without extra pronation control.
• Accommodating Fit: The double jacquard knit upper stretches and breathes while remaining durable, giving a roomy, comfortable feel especially in the toe box.
• Smooth Transitions: A broad platform plus tuned heel and forefoot help stabilize the foot and promote seamless heel-to-toe movement.
• Foot-Health Certifications: Certified PDAC A5500 for diabetic use and granted the APMA Seal of Acceptance, indicating clinical attention to comfort and fit.

Who It's For

The Glycerin 22 is best for neutral road runners seeking maximum cushioning and a soft ride, walkers who cover long distances and need supportive cushioning, and gym-goers who prefer plush shoes for cross training or classes. Its certifications also make it appealing to shoppers concerned with foot health and diabetic-friendly footwear.

Runners who require strong stability or motion control should consider supportive alternatives such as the Glycerin GTS line, while those needing a very precise race-day shoe may look for lighter, firmer trainers. Also note that sizing impressions vary among customers, so trying them on or checking retailer sizing guidance is advisable.

Pros & Cons

Pros

• Exceptional cushioning that reduces impact on knees and hips for long walks or runs.
• Roomy toe box and breathable knit upper deliver all-day comfort and a secure fit.
• Certified for diabetic use and APMA accepted, offering extra reassurance for foot health.

Cons

• Sizing feedback is mixed and some customers find they run small, so fit may require careful selection or a half size up.

Specifications

Model	Glycerin 22
Support Type	Neutral
Cushion Technology	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit, breathable and accommodating
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Brooks Womens Glycerin 22 is recommended for anyone who wants maximum, plush cushioning and smooth transitions on the road or at the gym; its DNA Tuned cushion and foot-health certifications add real value for walkers and runners who prioritize comfort. Size carefully, but for those who get the right fit it is a durable, comfortable choice that justifies the investment.

Frequently Asked Questions

Are these shoes good for long-distance walking?
Yes, customers report comfortable long-distance walking due to the plush midsole and roomy toe box.

Do these provide motion control for overpronation?
No, the Glycerin 22 is a neutral support shoe; consider the Glycerin GTS models for added support.

How do they fit compared with previous versions?
Fit impressions vary and some find they run small compared with predecessor models, so try them on or size up if unsure.