Brooks Womens Glycerin GTS 22 Running Shoe - Supportive Cushion

Our review of the Brooks Womens Glycerin GTS 22 finds a supportive, highly cushioned road running shoe best suited to runners and walkers who need stability without sacrificing plush comfort. The single biggest reason to consider them is the combination of GuideRails support and the new DNA Tuned cushioning, which together stabilize the foot while delivering soft landings and energetic toe-offs. Reviewers report reduced foot, hip and back discomfort after switching to these shoes, making them a strong option for anyone seeking support-oriented daily trainers.

Key Features

• GuideRails support: A holistic support system that keeps excess motion in check so the foot tracks in a natural path, helping reduce strain on knees and hips.
• DNA Tuned cushion: Dual-size midsole cells provide larger, softer heel cells for plush landings and smaller forefoot cells for responsive toe-offs.
• Accommodating upper: The double jacquard knit upper stretches where needed for comfort while remaining durable and breathable during longer runs.
• Smooth transitions: A broad platform combined with a tuned heel and forefoot smooth heel-to-toe movement for steady road cadence.
• Diabetic friendly design: Certified PDAC A5500 diabetic shoe, making it appropriate for users who need protective, accommodating footwear.

Who It's For

The Glycerin GTS 22 is ideal for women who want a supportive daily trainer for road running, cross training or gym sessions, especially those who benefit from extra arch and gait support. Runners with a history of foot, hip or back discomfort will appreciate the stable platform and cushioning that reduce impact-related pain.

These are less suited to racers or runners seeking a minimal, lightweight shoe; heel-to-toe smoothing and a cushioned platform add weight and a plush feel that some speed-focused athletes may find sluggish. Also, buyers who require a very wide toe box should try them on first, as customer feedback on toe space is mixed.

Pros & Cons

Pros

• Excellent stabilized support from the GuideRails system that helps control excess motion.
• Plush yet responsive feel from the DNA Tuned midsole, balancing soft landings with energetic toe-offs.
• Comfortable, breathable double jacquard knit upper that adapts to foot shape.
• Certified PDAC A5500 diabetic shoe for added protective use cases.

Cons

• Fit and sizing are mixed among customers; some report a narrower toe box while others find ample room.
• Cushioning preference varies, so runners who want firmer, minimal cushioning may prefer a different model.

Specifications

Brand	Brooks
Model	Glycerin GTS 22
Support system	GuideRails holistic support
Midsole technology	DNA Tuned dual-size cells
Upper	Double jacquard knit, breathable
Recommended use	Road running, cross training, gym
Certification	PDAC A5500 diabetic shoe

Our Verdict

The Brooks Womens Glycerin GTS 22 is a strong choice for women seeking a supportive, cushioned daily trainer that eases impact and stabilizes natural motion. Its GuideRails and DNA Tuned midsole deliver a comfortable, protective ride that represents good value for runners who prioritize comfort, orthotic-friendly fit and reduced joint strain.

Frequently Asked Questions

Are these shoes good for overpronation?
Yes. The GuideRails support system is designed to limit excess motion and help keep the foot in a natural path, which benefits mild to moderate overpronation.

Do they run true to size?
Fit reports are mixed; many find the length and overall fit true to size but some users report a narrower toe box, so trying them on or checking return options is recommended.

Can I use these every day and for walking?
Yes. The plush DNA Tuned cushioning and stable platform make them suitable for daily wear, walking and varied gym activities.