Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Cushioned 21

In this review the Brooks Womens Glycerin GTS 22 earns high marks for runners who need plush cushioning without sacrificing guidance. Built around the brand's latest midsole tech, the shoe balances soft landings with a propulsive toe-off and adds GuideRails support to limit excess motion, making it a strong choice for road runs, gym sessions and daily wear. The reviewer found the fit accommodating for many feet but notes some users report a narrow toe box, so comfort depends on foot shape.

Key Features

• GuideRails support: Keeps excess motion in check to help stabilize the knee and maintain a natural motion path during runs and cross training.
• DNA Tuned cushioning: Dual-size midsole cells deliver plush landings in the heel and responsive toe-offs for smoother transitions.
• Certified diabetic design: The shoe is a PDAC A5500 certified diabetic shoe, which signals extra attention to accommodation and comfort for those who need it.
• Double jacquard knit upper: Provides a flexible, breathable fit that adapts to the foot while offering durability for regular road use.
• Broad platform: Stabilizes the foot through heel-to-toe movement and supports a smoother stride on pavement and the treadmill.

Who It's For

The Glycerin GTS 22 is best for neutral to mild-overpronation runners who want a highly cushioned trainer with stability features, runners who spend a lot of time on pavement, and gym users who prioritize comfort and support. It also suits buyers who value a certified diabetic shoe for added peace of mind.

Runners with very wide forefeet or those who need a very roomy toe box should try them on first, since some customers report a narrower toe area. If you prefer a minimal, low-profile shoe or need maximal flexibility for trail running, a different model may be a better match.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that absorbs impact and eases long runs.
• GuideRails system offers sensible support without feeling intrusive.
• Breathable double knit upper balances stretch and structure for daily use.

Cons

• Some users report the toe box runs narrow, so sizing and fit can vary by foot shape.

Specifications

Our Verdict

The Glycerin GTS 22 is a compelling choice for runners seeking plush cushioning with built-in stability; its DNA Tuned midsole and GuideRails system deliver comfortable, smoother transitions and reliable support. For most road runners and gym users it represents good value, though anyone needing an extra-wide toe box should check fit before buying.

Frequently Asked Questions

Do these run true to size?
Fit varies: many find the length true to size but some customers report a narrower toe box, so try before you commit if you have wide forefeet.

Are they suitable for long runs?
Yes, the plush heel cushioning and responsive forefoot make them well suited to longer road runs where comfort and transition matter.

Can I use them for gym workouts?
Yes, the broad platform and GuideRails support make them versatile for gym sessions and cross training as well as road running.