Brooks Womens Glycerin GTS 22 Supportive Running Shoe - GuideRails

In this review of the Brooks Womens Glycerin GTS 22, the bottom line is simple: this shoe is for female runners and active walkers who want plush cushioning with added stability. The reviewer found the shoe delivers a soft, luxurious ride thanks to Brooks DNA Tuned midsole design and gives reliable lateral control via the GuideRails support system. It is also notable that the Glycerin GTS 22 is a certified PDAC A5500 diabetic shoe, making it a strong choice for anyone needing an accommodating, therapeutic fit without sacrificing everyday road-running performance.

Key Features

• GuideRails support: Keeps excess motion in check to stabilize the foot and reduce strain on the knees and hips during runs or gym sessions.
• DNA Tuned cushion: Larger heel cells and smaller forefoot cells combine for soft landings and responsive toe-offs that smooth transitions.
• Accommodating knit upper: The double jacquard knit stretches to relieve pressure points while offering breathability for longer outings.
• Broad platform: A wider base stabilizes the foot for steadier heel-to-toe movement on road surfaces and treadmills.
• PDAC A5500 certification: Recognized as a diabetic-friendly shoe, offering extra room and support where medical footwear is required.

Who It's For

The Glycerin GTS 22 suits women who run on roads, use the gym, or cross-train and who prioritize cushioning plus guidance to control excess motion. Runners with mild overpronation will appreciate the GuideRails system, and anyone seeking a plush, stable platform for daily miles or long walks will find this model comforting.

Those who need a very narrow racing shoe or extreme responsiveness for speed workouts may want a lighter, less cushioned option. Also, shoppers who consistently find shoes too tight in the toe box should check fit carefully, since customers reported mixed impressions about toe volume.

Pros & Cons

Pros

• Exceptional cushioning and smooth transitions from DNA Tuned midsole technology.
• Supportive GuideRails system that reduces excess motion and helps knee alignment.
• Accommodating double jacquard knit upper that balances breathability with a flexible fit.
• Certified PDAC A5500 diabetic shoe for medical-friendly use.

Cons

• Fit and toe box volume received mixed feedback, so some may find the front of the shoe narrow.
• Not the lightest option for fast tempo runs where minimal weight is preferred.

Specifications

Model	Glycerin GTS 22
Gender	Women
Support system	GuideRails holistic support
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Use	Road running, cross training, gym
Medical certification	PDAC A5500 diabetic shoe

Our Verdict

The Brooks Womens Glycerin GTS 22 is a strong value for female runners who want a plush, stable ride with built-in motion control. Its mix of cushioned DNA Tuned foam, GuideRails support, and an accommodating knit upper makes it ideal for everyday mileage, recovery runs, or anyone needing diabetic-friendly footwear without losing running comfort.

Frequently Asked Questions

Are these shoes good for overpronation?
Yes, the GuideRails support system is designed to keep excess motion at bay and assist runners with mild to moderate overpronation.

Do they run true to size?
Fit reports are mixed; some find plenty of toe room while others find the toe box narrow, so trying your usual running size or consulting a fitting guide is recommended.

Can I use these for gym and cross training?
Yes, the broad platform and stable transitions make them suitable for road running, gym use, and cross training activities.