Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth A5500

In this review of the Brooks Womens Glycerin GTS 22 Supportive Running Shoe the bottom line is simple: this is a highly cushioned, stability-focused trainer best suited to women who want plush landings and controlled motion. The Glycerin GTS 22 stands out for its combination of DNA Tuned cushion that balances soft heel cells with a responsive forefoot and the GuideRails support system that keeps excess motion in check. It is also notable as a certified PDAC A5500 diabetic shoe, which adds a practical benefit for runners and walkers who need extra foot protection and comfort.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide plush, comfortable landings while smaller forefoot cells encourage energetic toe-offs for smoother transitions.
• GuideRails Support: The holistic GuideRails system stabilizes the foot and reduces excess motion to help steady the knee and gait during runs or workouts.
• Accommodating Fit: The double jacquard knit upper delivers flexible, breathable coverage that adapts to the foot while remaining durable for regular use.
• Stable Platform: A broad midsole base and tuned heel-to-toe geometry promote steady, smooth heel-to-toe rolling through each stride.
• Certified Diabetic Option: Being a PDAC A5500 certified diabetic shoe makes it a practical choice for individuals needing footwear approved for therapeutic use.

Who It's For

The Glycerin GTS 22 is well suited to recreational road runners and gym users who prioritize cushioning and support over a minimal, racing-style ride. Runners with mild to moderate overpronation will appreciate the GuideRails system, while anyone seeking a comfortable daily trainer for walking, cross training, or long easy miles will find the fit and cushion inviting.

Those who prefer a wide, roomy toe box or a very lightweight, minimal shoe should look elsewhere; some customers report a narrower toe area and the GTS version is heavier than neutral low-profile trainers. Also, if you want a firmer, race-focused platform, this shoe's plush feel may seem too soft.

Pros & Cons

Pros

• Exceptional cushioning and smooth transitions thanks to the DNA Tuned midsole.
• Reliable lateral and medial support from the GuideRails system for steadier strides.
• Comfortable, breathable, and durable double jacquard knit upper for accommodating fit.
• Certified PDAC A5500 diabetic shoe adds medical and comfort value.

Cons

• Some wearers find the toe box narrow, so sizing may require trying a half size up for comfort.
• The extra cushioning and support add weight compared with lightweight racing flats.

Specifications

Our Verdict

The Brooks Womens Glycerin GTS 22 is a compelling pick for runners and active women who want plush cushioning combined with purposeful stability. Its DNA Tuned midsole and GuideRails support deliver comfortable, controlled miles, and the diabetic certification is a meaningful plus. It represents good value for anyone prioritizing comfort and support, though those needing a wider toe box or a lighter race shoe should consider alternatives.

Frequently Asked Questions

Do these run true to size?
Fit varies; some customers find them true to size while others report a slightly narrow toe box and may prefer a half size up.

Are these suitable for everyday walking?
Yes, the plush cushioning and stable platform make them comfortable for daily walking, walking workouts, and long easy runs.

Is this shoe good for overpronation?
Yes, GuideRails support is designed to limit excess motion and assist runners with mild to moderate overpronation.