Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth at

In this review of the Brooks Womens Glycerin GTS 22 Supportive Running Shoe the bottom line is simple: this is a cushioned, stability-focused road shoe for women who want plush landings with controlled motion. The Glycerin GTS 22 stands out for its DNA Tuned midsole that blends larger heel cells with smaller forefoot cells for soft heel strikes and energetic toe-offs, plus GuideRails support to curb excess motion. It is a sensible choice for runners and gym-goers who prioritize comfort, arch support, and smooth transitions.

Key Features

• GuideRails support: Keeps excess motion at bay to help stabilize the foot and reduce strain on knees and hips during runs and cross training.
• DNA Tuned cushion: Larger cells in the heel provide plush landings while smaller forefoot cells promote responsive toe-offs for efficient transitions.
• Accommodating fit: The double jacquard knit upper offers flexible stretch and breathability while retaining structure for daily training.
• Broad platform: A wider base stabilizes the foot and supports smoother heel-to-toe movement on road surfaces.
• Certified diabetic option: The shoe is a PDAC A5500 certified diabetic shoe, offering extra consideration for foot health needs.

Who It's For

The Glycerin GTS 22 is best for road runners and fitness enthusiasts who want maximum cushioning plus targeted support to manage overpronation or reduce uncomfortable motion. It works well for long runs, recovery days, treadmill sessions, and everyday wear when cushioning and stability matter.

Runners who prefer minimal or very firm, race-day shoes should look elsewhere, as this model leans toward plush cushioning and a supportive platform rather than a lightweight, stripped-down feel. Also, those needing a very wide toe box may want to try sizing or a different model because customer reports on toe-box width vary.

Pros & Cons

Pros

• Excellent cushioning that soothes foot pain and reduces hip and back discomfort for many users.
• GuideRails system provides notable stability and support through the gait cycle.
• Breathable double jacquard knit upper balances comfort and durability for daily training.
• Certified PDAC A5500 diabetic shoe, offering an option for foot-sensitive users.

Cons

• Fit and toe-box width receive mixed feedback, so some may find the forefoot narrow or need to experiment with sizing.
• Plush cushioning may feel too soft for runners who want a very responsive, race-oriented ride.

Specifications

Brand	Brooks
Model	Glycerin GTS 22
Support	GuideRails holistic support
Cushioning	DNA Tuned midsole with varied cell sizing
Upper	Double jacquard knit, breathable and accommodating
Use	Road running, cross training, gym, everyday wear
Certification	PDAC A5500 diabetic shoe

Our Verdict

The Glycerin GTS 22 is a strong choice for women seeking a plush, stable road shoe that eases impact and supports natural motion. With DNA Tuned cushioning and GuideRails support it pairs comfort with controlled stability, making it good value for runners who prioritize long-run comfort, recovery days, or joints-friendly everyday training.

Frequently Asked Questions

Are these shoes good for overpronation?
Yes, the GuideRails support system is designed to limit excess motion and help stabilize runners who overpronate.

Do they run true to size?
Fit reports are mixed; many find a comfortable fit but some report a narrower toe box, so trying your usual size or half size adjustments is advisable.

Can these be used for gym and cross training?
Yes, the broad platform and cushioning make them suitable for road running, gym workouts, and cross-training sessions.