Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth cells

In this review of the Brooks Womens Glycerin GTS 22, the bottom line is simple: runners who need plush cushioning plus reliable stabilization will appreciate these shoes. The Glycerin GTS 22 pairs Brooks DNA Tuned cushion with GuideRails support to deliver soft landings and controlled, smooth toe-offs, making them a strong choice for road running, gym work and everyday wear. Comfort and support are the standout reasons to buy; the shoe is also a certified PDAC A5500 diabetic shoe, which reinforces its accommodating, protective fit.

Key Features

• GuideRails support: Keeps excess motion in check to stabilize the foot and reduce strain during long runs or cross training.
• DNA Tuned cushion: Larger heel cells provide plush landings while smaller forefoot cells promote energetic, responsive toe-offs.
• Accommodating knit upper: The double jacquard knit offers a flexible, breathable fit that adapts to the foot for extended comfort.
• Broad platform: A wide base helps stabilize the foot and smooths heel-to-toe transitions for a steady ride.
• Certified diabetic design: PDAC A5500 certification indicates the shoe meets standards for therapeutic and protective footwear.

Who It's For

The Glycerin GTS 22 is best for women who prioritize cushioning with support: daily road runners, walkers who want extra stability, and gym-goers who need a plush but guided platform. Those with midfoot to high arches who enjoy a soft landing but still want controlled motion will find the combination of DNA Tuned cushioning and GuideRails especially useful.

Runners seeking an ultra-light racing flat or minimal shoe should look elsewhere, as this model emphasizes cushioning and structure over extreme lightweight performance. Also, if you need a very narrow fit, the accommodating toe area reported by some customers suggests trying a different model or sizing carefully.

Pros & Cons

Pros

• Excellent cushioning that many customers describe as life-changing for long runs and daily wear.
• Reliable GuideRails support keeps excess motion under control without feeling intrusive.
• Comfortable, breathable knit upper that adapts to the foot for extended use.

Cons

• Fit opinions vary: some find the toe box roomy while others report a snug fit, so sizing may require try-on or ordering both sizes.

Specifications

Our Verdict

The Brooks Womens Glycerin GTS 22 is a strong pick for runners and walkers who want plush cushioning combined with thoughtful support. Its DNA Tuned midsole and GuideRails system deliver a comfortable, controlled ride that holds up for road running, cross training and daily wear, offering good value for anyone prioritizing comfort and stability.

Frequently Asked Questions

Are these shoes good for long runs?
Yes. The DNA Tuned cushioning and broad platform provide soft landings and stable transitions suitable for extended road runs.

Do they run true to size?
Customers report mixed fit experiences; some find extra room in the toe while others feel snug, so trying them on or checking retailer sizing guidance is recommended.

Are they suitable for diabetic feet?
Yes. The Glycerin GTS 22 is PDAC A5500 certified, indicating it meets standards for therapeutic diabetic footwear.