Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth DNA

In this review of the Brooks Womens Glycerin GTS 22 Supportive Running Shoe the bottom line is simple: this is a cushioning-first trainer for women who want plush landings and extra stabilization. The Glycerin GTS 22 blends Brooks' latest DNA Tuned midsole for soft heel impacts and springy toe-offs with the GuideRails support system that controls excess motion, making it a reliable option for road running, gym work and long daily miles where comfort and stability matter most.

Key Features

• GuideRails support: Keeps excess movement in check to help stabilise the foot and reduce strain through the gait cycle during runs or cross training.
• DNA Tuned cushion: Larger midsole cells in the heel and smaller forefoot cells provide a plush landing followed by a responsive toe-off for smoother transitions.
• Accommodating fit: The double jacquard knit upper flexes with the foot and offers breathability while still holding shape over longer wear.
• Broad platform: A wider base stabilizes the foot and contributes to steady heel-to-toe motion on road surfaces.
• Certified diabetic-friendly: The shoe is PDAC A5500 certified, indicating it meets requirements for therapeutic footwear for users who need that feature.

Who It's For

The Glycerin GTS 22 is best for female runners who prioritise plush cushioning and support - think daily road miles, recovery runs, or mixed gym sessions where comfort is a top concern. Runners with mild overpronation who want a stable, cushioned feel without the rigid structure of a motion-control shoe will find the GuideRails helpful.

Shoppers seeking an ultra-narrow racer, a minimalist shoe, or a shoe aimed purely at speedwork should look elsewhere; this model leans toward cushioning and stability rather than extreme responsiveness or very roomy toe boxes for those who need extra width.

Pros & Cons

Pros

• Exceptional day-to-day cushioning with DNA Tuned geometry for soft landings and lively toe-offs.
• Support from GuideRails gives confidence to runners who need motion control without bulky hardware.
• Comfortable, breathable knit upper that adapts to the foot while maintaining structure.

Cons

• Some users report a slightly narrow toe box, so wider-footed shoppers should try before committing.

Specifications

Model	Glycerin GTS 22
Support system	GuideRails holistic support
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable and flexible
Intended use	Road running, cross training, gym
Certification	PDAC A5500 Diabetic shoe certified

Our Verdict

The Brooks Womens Glycerin GTS 22 is a strong pick for runners who want luxurious cushioning combined with sensible support. Its tuned midsole and GuideRails system provide comfortable, stable miles for daily training and recovery runs, representing good value for anyone prioritising long-run comfort and gait guidance.

Frequently Asked Questions

Are these shoes good for overpronation?
Yes, the GuideRails support is designed to limit excess motion and offers help for mild to moderate overpronation while maintaining cushioning.

Do they run true to size?
Fit reports vary; some wearers find the toe box a bit narrow, so try on in-store or consider sizing options if you have a wider forefoot.

Can I use them for gym workouts?
Yes, they work well for road running and cross training, though they are primarily designed for cushioned running and stability rather than heavy lateral court sports.