Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth help

In this review of the Brooks Womens Glycerin GTS 22, the bottom line is simple: this shoe is for runners and active women who want plush cushioning paired with guided stability. The Glycerin GTS 22 stands out because its DNA Tuned midsole blends larger heel cells and smaller forefoot cells to deliver soft landings and energetic toe-offs while the GuideRails system controls excess motion. Reviewers consistently report relief from foot pain and improved overall comfort, making it a strong contender for road running, gym sessions, and everyday wear when support matters.

Key Features

• GuideRails support: Keeps excess motion in check to stabilize the foot and reduce stress on knees and hips during runs and cross training.
• DNA Tuned cushion: Larger midsole cells in the heel provide plush landings while smaller forefoot cells encourage responsive toe-offs for smoother transitions.
• Accommodating fit: The double jacquard knit upper stretches where needed and breathes well for long runs and all-day wear.
• Stable platform: A broad base combined with tuned heel and forefoot geometry promotes steady heel-to-toe roll.
• Diabetic certified: This model is a PDAC A5500 certified diabetic shoe, offering an option for those needing therapeutic footwear.

Who It's For

The Glycerin GTS 22 is best for women who want a highly cushioned road shoe that still offers meaningful support for mild to moderate overpronation. It suits runners who prioritize comfort and joint protection, people returning from foot pain, and gym-goers who value a plush platform for mixed workouts.

Those who prefer a very narrow race-day racer or want an extremely low-profile feel should look elsewhere; this shoe emphasizes cushioning and stability over minimal weight. Also, shoppers needing a guaranteed wide toe box should try on the shoe first, as customer feedback on toe space is mixed.

Pros & Cons

Pros

• Comfortable, plush cushioning that eases impact on heels and joints.
• GuideRails system provides dependable support and helps prevent excess motion.
• Breathable knit upper that adapts to foot shape for long-wear comfort.
• PDAC A5500 diabetic shoe certification adds therapeutic value.

Cons

• Fit and toe box width receive mixed feedback, so sizing may require trying on first.
• Heavier, cushioned design may not satisfy runners seeking a minimal, lightweight shoe.

Specifications

Model	Glycerin GTS 22 (successor to Glycerin GTS 21)
Support system	GuideRails holistic support
Cushioning	DNA Tuned midsole with varied cell sizes
Upper	Double jacquard knit, breathable and accommodating
Primary use	Road running, cross training, gym and everyday wear
Certification	PDAC A5500 diabetic shoe certified

Our Verdict

The Brooks Womens Glycerin GTS 22 is a solid choice for women who want maximum cushioning with built-in stability. It delivers a luxurious ride, reliable GuideRails support, and therapeutic certification, making it good value for runners needing comfort and motion control. Try a pair in-store if you are concerned about toe-box width, but for most buyers this shoe blends protection and responsiveness well.

Frequently Asked Questions

Are these shoes good for daily running?
Yes, the Glycerin GTS 22 is designed for road running and daily training with cushioning and support for regular use.

Do they help with overpronation?
They provide guided stability via the GuideRails system to limit excess motion and support a natural stride.

Is the fit roomy?
Fit reports are mixed; the knit upper is accommodating but some users find the toe box narrow, so trying them on is recommended.