Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth IS

In this review of the Brooks Womens Glycerin GTS 22 Supportive Running Shoe, the bottom line is simple: it is for women who want plush cushioning plus added stability in daily runs and workouts. The Glycerin GTS 22 pairs Brooks' latest DNA Tuned midsole with the GuideRails support system to deliver soft landings and controlled motion, making it a strong pick for runners who prioritize comfort and joint-friendly transitions. Reviewers praise the shoe for comfort and support while noting some variability in toe box fit.

Key Features

• GuideRails support: Keeps excess motion in check so the foot tracks in a natural path and helps stabilize longer runs and cross training sessions.
• DNA Tuned midsole: Larger heel cells offer plush landings while smaller forefoot cells make toe-offs feel springy and responsive.
• Accommodating knit upper: A double jacquard knit delivers breathability and a flexible fit that adapts to foot shape during activity.
• Broad platform: A wider base stabilizes the foot for smooth heel-to-toe transitions and confidence on road surfaces.
• Diabetic shoe certification: The model is a certified PDAC A5500 diabetic shoe for customers needing extra footwear accommodations.

Who It's For

The Glycerin GTS 22 is aimed at women who run on roads, use mixed gym workouts, or want a cushioned shoe for daily wear; it suits those who need extra support from a holistic system rather than a minimalist trainer. Runners with mild overpronation will appreciate the GuideRails stabilization paired with the plush DNA Tuned cushioning.

Shoppers who need a very wide toe box or who prefer a totally minimal, lightweight shoe should look elsewhere; some customers report the toe box can feel narrow for certain foot shapes. If a race-day featherweight spike is the goal, a lighter racing shoe would be a better match.

Pros & Cons

Pros

• Excellent overall comfort and life-changing feeling cushioning for long training runs.
• Supportive GuideRails system that reduces excess motion without feeling intrusive.
• Durable, breathable knit upper that adapts to the foot and looks subtle and stylish.
• Certified PDAC A5500 diabetic shoe for users needing special footwear options.

Cons

• The toe box may run narrow for some users, so trying before committing is advisable.
• Not the lightest option for competitive racing where minimal weight matters.

Specifications

Model	Glycerin GTS 22
Support system	GuideRails holistic support
Cushioning technology	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit, breathable and flexible
Platform	Broad platform for stable transitions
Certification	PDAC A5500 diabetic shoe
Predecessor	Glycerin GTS 21

Our Verdict

The Glycerin GTS 22 is a strong choice for women seeking a plush, stable daily trainer that balances cushioning with guided support; its DNA Tuned midsole and GuideRails system make it especially worthwhile for those with joint concerns or mild overpronation. It represents good value for runners who prioritize comfort and durability, though shoppers with very wide toes or race-day weight needs should evaluate fit and alternatives first.

Frequently Asked Questions

Are these shoes good for overpronation?
The GuideRails system is designed to limit excess motion, making the Glycerin GTS 22 suitable for mild overpronation and added stability during runs.

Do they run true to size?
Customers disagree on sizing; while many find the length true, some report the toe box feels narrow, so try on or size conservatively if you have a wider forefoot.

Can I use them for the gym as well as running?
Yes, the combination of cushioning and stabilizing support makes them appropriate for road running, cross training, and general gym use.