Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth midsole

In this review of the Brooks Womens Glycerin GTS 22 the bottom line is simple: this is a highly cushioned, stability-focused road running shoe for women who want plush landings and controlled motion. The Glycerin GTS 22 stands out for its combination of DNA Tuned midsole cushioning and the GuideRails support system, which together create smooth heel-to-toe transitions and steady support on runs, gym sessions, or long days on your feet. For runners who prioritize comfort and stability, this shoe delivers one clear reason to buy - outstanding, consistent cushioning paired with holistic support.

Key Features

• GuideRails support: Keeps excess motion in check to stabilize the foot and protect the knees during runs or cross training.
• DNA Tuned cushion: Dual-size midsole cells give soft, plush landings in the heel and responsive toe-offs in the forefoot for balanced energy return.
• Accommodating fit: The double jacquard knit upper stretches where you need it and breathes well for longer wear and improved comfort.
• Smooth transitions: A broad platform plus a tuned heel and forefoot help create a stable, smooth heel-to-toe roll.
• Certified diabetic friendly: This model is a PDAC A5500 certified diabetic shoe, offering an option for runners needing extra foot protection.

Who It's For

The Glycerin GTS 22 is best for female road runners, walkers, and gym-goers who want maximum cushioning along with reliable stability. It suits those who appreciate a plush ride and the added confidence of GuideRails when they need to limit excess motion.

Runners who prefer a very narrow toe box or a minimal, firm ride should look elsewhere; some wearers found the toe area tighter than expected and a few noted the shoes run differently than previous models. If you need a race-flat or a low-profile trainer, there are lighter, less-cushioned alternatives.

Pros & Cons

Pros

• Exceptional cushioning that makes long runs feel less taxing on the joints.
• GuideRails deliver noticeable support for overpronation without feeling intrusive.
• Comfortable, breathable knit upper that adapts to foot shape during activity.
• Certified PDAC A5500 diabetic shoe, an important benefit for users needing protective footwear.

Cons

• The toe box may feel narrow for some users, so fit can vary and trying them on is advisable.
• Heavier and plusher than minimal trainers, so not ideal for speed-focused race days.

Specifications

Model	Glycerin GTS 22
Support Type	GuideRails stability system
Cushioning	DNA Tuned dual-cell midsole (heel and forefoot tuned)
Upper	Double jacquard knit, breathable and accommodating
Primary Use	Road running, cross training, gym wear
Certification	PDAC A5500 diabetic shoe
Predecessor	Glycerin GTS 21

Our Verdict

The Brooks Womens Glycerin GTS 22 is an excellent choice for women who want plush cushioning plus dependable stability for everyday runs and longer training sessions. Its DNA Tuned midsole and GuideRails system combine to reduce fatigue and support natural motion, making it good value for runners who prioritize comfort and injury-conscious design.

Frequently Asked Questions

Are these shoes good for overpronation?
Yes. The GuideRails support system is designed to limit excess motion and help stabilize the foot for runners who overpronate.

Do they run true to size?
Fit can vary; some customers report a narrower toe box so trying them on or checking return options is recommended.

Can I use them for gym training as well as running?
Yes. Their supportive platform and cushioning make them suitable for road running, cross training, and general gym use.