Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth PDAC

In this review of the Brooks Womens Glycerin GTS 22, the bottom line is clear: this shoe is for women who want plush cushioning with reliable stability on road runs and everyday workouts. The single biggest reason to buy is the combination of Brooks DNA Tuned cushioning and GuideRails support, which delivers soft landings and controlled motion in a package that also fits like a breathable knit. For runners seeking a stable, comfortable daily trainer, the Glycerin GTS 22 stands out for its comfort and smooth transitions.

Key Features

• GuideRails support: Keeps excess motion in check so the foot tracks more naturally and feels more stable on long runs or cross training.
• DNA Tuned cushion: Larger heel cells and smaller forefoot cells create plush landings with responsive toe-offs for smoother stride transitions.
• Accommodating fit: The double jacquard knit upper stretches where needed and breathes well for long wear without feeling constrictive.
• Broad stable platform: A wider base stabilizes the foot for steady heel-to-toe roll and reduces the sense of wobble on hard surfaces.
• Certified diabetic-friendly: The shoe is a PDAC A5500 certified diabetic shoe, offering an accommodating interior for sensitive feet.

Who It's For

The Glycerin GTS 22 is best for recreational and distance runners who want a plush, supportive daily trainer that tames excess motion without feeling overly rigid; it also suits walkers and gym frequenters who favor cushioning and stability. Its knit upper and cushioned midsole make it appealing for anyone who prioritizes comfort and smooth heel-to-toe transitions.

Runners who need an extremely wide toe box or prefer minimal, highly responsive racing flats should look elsewhere, as some users report the toe box can feel narrow. Those seeking a lightweight racing shoe will find the Glycerin GTS 22 more oriented toward everyday comfort and support than top-end speed.

Pros & Cons

Pros

• Excellent comfort and cushioning that many customers describe as life-changing for long miles.
• GuideRails deliver tangible support and reduce excess motion during runs.
• Durable, breathable double jacquard knit upper provides a flexible, accommodating fit.
• Certified PDAC A5500 diabetic shoe for users who need an accommodating interior.

Cons

• Some wearers find the toe box too narrow, so those with very wide toes may need a different model.
• Perceived value varies among buyers; some feel the price is high for this level of performance.

Specifications

Model	Glycerin GTS 22
Support system	GuideRails holistic support
Midsole technology	DNA Tuned cushioning with dual-size cells
Upper	Double jacquard knit for breathability and flexibility
Recommended use	Road running, cross training, gym
Diabetic certification	PDAC A5500 certified
Predecessor	Glycerin GTS 21

Our Verdict

The Brooks Womens Glycerin GTS 22 is a strong choice for women seeking plush cushioning paired with guided stability; it excels as a daily trainer for road miles and mixed workouts. While the toe box may feel narrow to some, the combination of DNA Tuned cushioning and GuideRails makes it a worthwhile buy for runners who value comfort, controlled motion, and a breathable fit.

Frequently Asked Questions

Are these good for everyday running?
Yes, the Glycerin GTS 22 is designed for road running and daily training thanks to its cushioned midsole and stable platform.

Do they run true to size?
Customers disagree; some find the fit true to size while others note the toe box can feel narrow, so consider trying them on or ordering a half size up if you have wide toes.

Is this shoe supportive enough for overpronation?
Yes, the GuideRails support system helps control excess motion and provides additional stability for runners who need it.