Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth Prepare

Our review of the Brooks Womens Glycerin GTS 22 finds a generously cushioned, stability-focused trainer best suited for women who want plush daily miles with extra motion control. The clearest reason to buy is the combination of Brooks DNA Tuned cushioning with GuideRails support, which delivers soft heel landings, responsive toe-offs and controlled alignment for runners who need protection without a rigid ride. Fit is accommodating in the knit upper, though some wearers report a narrower toe box, so sizing and personal foot shape matter.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel and smaller cells in the forefoot provide a soft, plush landing followed by an energetic toe-off for smoother transitions.
• GuideRails Support: The holistic GuideRails system keeps excess motion in check to help stabilize the foot and reduce strain on knees and hips during runs.
• Accommodating Knit Upper: The double jacquard knit upper stretches where needed while remaining breathable and durable for daily training and gym sessions.
• Broad Platform: A wider sole stabilizes the foot and helps the tuned heel and forefoot produce consistent heel-to-toe roll.
• Versatile Use: Designed for road running, cross training and gym work, offering the comfort and support needed across different types of workouts.

Who It's For

The Glycerin GTS 22 is ideal for runners who prioritize cushioning plus stability, such as recreational road runners, walkers with mild overpronation, or anyone who logs long, easy miles and wants protective midsole foam and GuideRails support. It also suits gym-goers who prefer a soft, supportive base for cross training.

Those seeking a narrow racing flat, minimal shoe, or a radically wider toe box should look elsewhere; some customers note the toe box can feel snug. If ultra-lightweight speed work is your priority, this plush, supportive trainer will feel heavier than race-focused models.

Pros & Cons

Pros

• Exceptional cushioning that combines soft heel landings with springy toe-offs.
• GuideRails support reduces excess motion for a more stable run.
• Comfortable, breathable double jacquard knit upper that adapts to the foot.
• Certified PDAC A5500 diabetic shoe, offering added assurance for users needing accommodative footwear.

Cons

• The toe box can run narrow for some wearers, so try before committing to a regular size.

Specifications

Model	Glycerin GTS 22
Support System	GuideRails holistic support
Cushion Technology	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit, breathable and durable
Best For	Road running, cross training, gym use
Certification	PDAC A5500 diabetic shoe

Our Verdict

The Glycerin GTS 22 is a strong choice for runners who want plush cushioning plus reliable support; its DNA Tuned midsole and GuideRails system create smooth, stable transitions that protect knees and ankles. For everyday training, long runs and mixed workouts it represents good value for buyers who prioritize comfort and stability over minimal weight or a roomy toe box.

Frequently Asked Questions

Are these shoes good for overpronation?
Yes. The GuideRails support is designed to limit excess motion and assist runners with mild to moderate overpronation.

Do they run true to size?
Fit can vary; many find the knit upper accommodating, but some customers report the toe box feels narrow, so try them on if possible.

Can I use these for gym workouts?
Yes. They work well for road running and cross training or general gym use thanks to the stable broad platform and cushioned midsole.