Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth Tuned

In this review the Brooks Womens Glycerin GTS 22 stands out as a cushioned, supportive road running shoe best suited to runners who want plush landings without sacrificing stability. The single biggest reason to consider the Glycerin GTS 22 is its DNA Tuned midsole combined with GuideRails support, which together deliver a soft heel strike and guided, smooth transitions through toe-off. It also offers an accommodating knit upper and is certified as a PDAC A5500 diabetic shoe, making it a strong option for anyone needing extra support and comfort on daily runs or long walks.

Key Features

• GuideRails support: Keeps excess motion in check so the foot and body stay aligned during runs, reducing strain on hips and knees.
• DNA Tuned cushion: Larger heel cells provide plush landings while smaller forefoot cells promote responsive toe-offs for a balanced ride.
• Accommodating fit: The double jacquard knit upper flexes to the foot for breathability and comfort while remaining durable for regular use.
• Smooth transitions: A broad platform with a tuned heel and forefoot stabilizes the foot for consistent heel-to-toe roll.
• PDAC A5500 certified: Classified as a diabetic-friendly shoe, offering features suited to users who need protective, comfortable footwear.

Who It's For

The Glycerin GTS 22 is ideal for women road runners and fitness walkers who prioritize plush cushioning with dependable support. It works well for everyday training, cross training, gym sessions, and long walks where comfort and stabilization are priorities.

Runners who prefer an ultra-wide toe box or a firmer, minimalist ride may want to look elsewhere; some users report mixed experiences with toe-box width and subjective cushioning levels, so those with very specific fit preferences should try them on before committing.

Pros & Cons

Pros

• Generous, cushioned ride that reduces impact on the heel and lower joints.
• GuideRails system provides noticeable medial-lateral support for stabilized gait.
• Breathable double jacquard knit upper balances flexibility with durability.
• PDAC A5500 certification makes it suitable for users needing diabetic-friendly footwear.

Cons

• Fit can be inconsistent; some users find the toe box narrow while others report roomier fit.
• Cushion feel is subjective and may be too plush for runners who prefer firmer responsiveness.

Specifications

Brand	Brooks
Model	Glycerin GTS 22
Support system	GuideRails holistic support
Cushion technology	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit for breathability and flexibility
Use	Road running, cross training, gym and everyday wear
Special certification	PDAC A5500 diabetic shoe

Our Verdict

The Brooks Glycerin GTS 22 is a compelling choice for women who need a plush, stable running shoe that also supports natural motion. Its DNA Tuned cushioning paired with GuideRails makes it good value for everyday runners and those seeking relief from foot-related discomfort, though shoppers should confirm fit if they have a narrow or unusually wide toe box.

Frequently Asked Questions

Are these shoes good for long runs?
Yes, the plush DNA Tuned cushioning and stable platform make them comfortable for long road runs and extended wear.

Do they provide support for overpronation?
The GuideRails support system helps control excess motion and supports a more stable gait for mild to moderate overpronation.

Are they suitable for diabetic foot care?
Yes, the Glycerin GTS 22 is PDAC A5500 certified, indicating features appropriate for many users who need diabetic-friendly footwear.