Brooks Womens Glycerin GTS 22 Supportive Running Shoe - Smooth Women's

Our review of the Brooks Womens Glycerin GTS 22 finds it is best for women seeking plush cushioning with built-in stability. The standout is the midsole: Brooks' DNA Tuned system blends larger heel cells for soft landings and smaller forefoot cells for responsive toe-offs, giving a noticeably smooth transition with each stride. Paired with GuideRails support, the Glycerin GTS 22 focuses on controlling excess motion without feeling rigid, which makes it a strong choice for road runners and gym goers who want comfort plus structure in one shoe.

Key Features

• GuideRails support: Keeps excess motion at bay to help stabilize the foot and protect the knees during longer runs or cross training sessions.
• DNA Tuned cushion: Larger cells in the heel and smaller cells in the forefoot create a balance of soft landings and energetic toe-offs for smoother transitions.
• Acccommodating knit upper: The double jacquard knit offers breathable stretch and a comfortable wrap while remaining durable for frequent use.
• Broad platform: A wider sole base improves stability and helps the foot feel planted through heel-to-toe movement.
• Diabetic-friendly certification: Certified PDAC A5500, indicating construction appropriate for some diabetic footcare needs.

Who It's For

The Glycerin GTS 22 is ideal for women who want a plush, supportive road shoe that eases impact without sacrificing responsiveness; it suits daily miles, treadmill runs, and mixed gym work where cushioning and stability matter. Runners who appreciate a soft heel strike but still want guidance through toe-off will notice the DNA Tuned midsole improves gait feel.

Those who need an ultra-wide toe box or a minimalist, highly responsive racing shoe should look elsewhere; a few customers report the toe box can feel narrower than expected. Also, if you prefer a very firm, road-racing feel, the plush cushioning here may feel too soft.

Pros & Cons

Pros

• Exceptional cushioned ride that reduces impact on longer runs and daily use.
• GuideRails support offers controlled stability without feeling restrictive.
• Breathable, flexible knit upper provides a comfortable, accommodating fit.
• Certified PDAC A5500 for diabetic-friendly construction adds practical value.

Cons

• Some users find the toe box on the narrow side, so sizing or width options may be needed.
• Not the best choice for runners seeking a firm, race-day shoe or a highly minimalist feel.

Specifications

Brand	Brooks
Model	Glycerin GTS 22 (predecessor: Glycerin GTS 21)
Support Type	GuideRails holistic support
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit, breathable and accommodating
Use	Road running, cross training, gym
Certification	PDAC A5500 diabetic shoe

Our Verdict

The Brooks Womens Glycerin GTS 22 is a strong pick for runners and active women who prioritize plush cushioning plus reassuring stability. Its DNA Tuned midsole and GuideRails support deliver smooth, protected transitions and comfortable daily wear, making it good value for anyone needing extra support and comfort; just confirm fit in the toe box if you typically require a roomier forefoot.

Frequently Asked Questions

Are these shoes good for long road runs?
Yes, the DNA Tuned cushioning and broad platform create soft landings and stable transitions suitable for long miles on pavement.

Do they offer stability without feeling stiff?
Yes, GuideRails provide holistic support that controls excess motion while maintaining a comfortable, non-restrictive feel.

Do they fit wide feet comfortably?
Some customers report a narrower toe box, so those with wide forefeet should try them on or consider a wider size option if available.