Brooks Womens Glycerin GTS 22 Supportive Running Shoe (Style R51W)

In this review of the Brooks Womens Glycerin GTS 22 Supportive Running Shoe the bottom line is clear: this is a cushioned, stability-focused road shoe for runners and walkers who need extra support without sacrificing plush comfort. It stands out for its combination of GuideRails holistic support and the new DNA Tuned midsole that delivers a soft heel landing and energetic toe-offs. Reviewers who value pain relief, dependable arch support and a smooth heel-to-toe transition will find the Glycerin GTS 22 an excellent choice.

Key Features

• GuideRails support: Holds excess motion in check to stabilize the knee and help maintain a natural motion path during runs and daily wear.
• DNA Tuned cushion: Larger midsole cells in the heel and smaller cells in the forefoot provide plush landings and responsive toe-offs for smoother transitions.
• Accommodating fit: The double jacquard knit upper is flexible and breathable so the shoe adapts to the foot while remaining durable for frequent use.
• Broad stable platform: The wider base stabilizes the foot through heel-to-toe roll, reducing wobble on road runs and light cross training.
• Certified diabetic option: The Glycerin GTS 22 is PDAC A5500 certified, making it suitable for walkers with specific diabetic footwear needs.

Who It's For

The Glycerin GTS 22 is best for women who want a plush, highly cushioned road running shoe with added support for overpronation or general stabilization needs. It fits runners who prioritize comfort and protection from foot pain, and it works well for gym sessions, cross training, and long walking days where cushioning and stability matter.

Runners who prefer an extremely narrow racing fit or minimal, zero-drop shoes should look elsewhere; this model emphasizes cushioning and structural support over lightweight minimalism. Also, those who need a very roomy toe box may want to try it on first, as customer feedback on toe space is mixed.

Pros & Cons

Pros

• Exceptional cushioning and smooth transitions thanks to the DNA Tuned midsole.
• GuideRails system provides tangible support for excess motion and improved stability.
• Breathable, flexible double jacquard knit upper offers an accommodating fit and durability.
• PDAC A5500 certification makes it a practical option for diabetic foot care requirements.

Cons

• Fit and toe box width receive mixed feedback, so sizing can vary between feet and may require trying on.
• Heavier and more supportive than minimal running shoes, so not ideal for those seeking a lightweight racer.

Specifications

Our Verdict

The Brooks Glycerin GTS 22 is a smart pick for women seeking a supportive, plush running shoe that eases foot pain and stabilizes gait. Its DNA Tuned cushioning and GuideRails support deliver comfortable, smooth transitions and make it good value for runners who want cushioning plus structure rather than a minimalist feel.

Frequently Asked Questions

Are these shoes good for overpronation?
Yes, the GuideRails support is designed to control excess motion and provide stability for overpronation without harsh correction.

Do they run true to size?
Fit reports are mixed; some users find plenty of room in the toe while others experience a narrower toe box, so trying them on or checking return options is advised.

Can these be used for diabetic foot care?
Yes, the Glycerin GTS 22 is PDAC A5500 certified, making it suitable for diabetic shoe needs when recommended by a clinician.