Brooks Womens Glycerin GTS 22 Supportive Running Shoe (Style WFY5)

In this review of the Brooks Womens Glycerin GTS 22 Supportive Running Shoe the bottom line is simple: it is for runners and walkers who want plush cushioning with guided stability. The shoe pairs Brooks DNA Tuned cushion technology with the GuideRails support system to deliver soft landings and controlled motion, making it especially appealing to people who value comfort over long miles or need extra stability. As a certified PDAC A5500 diabetic shoe, it also suits those who need an accommodating, protective fit without sacrificing responsive toe-offs.

Key Features

• GuideRails Support: Helps keep excess motion in check so feet and knees stay aligned on road runs and in the gym.
• DNA Tuned Cushion: Larger heel cells create plush landings while smaller forefoot cells provide a more energetic toe-off.
• Accommodating Fit: The double jacquard knit upper stretches and breathes to reduce pressure points and improve overall comfort.
• Smooth Transitions: A broad platform with a tuned heel and forefoot promotes stable heel-to-toe movement for a confident stride.
• Diabetic Friendly: Certified PDAC A5500 status indicates suitability for users who need extra protective footwear.

Who It's For

The Glycerin GTS 22 is best for road runners, gym users, and everyday walkers who prioritize cushioning and supportive control during movement. It works well for people who experience mild overpronation or who appreciate guided stability without a rigid orthotic feel, and the plush heel-to-toe ride suits longer training sessions or recovery runs.

Runners seeking a minimal, racing-focused shoe or those who require an especially wide toe box may want to look elsewhere, as some customers report a narrower toe area and mixed opinions on true-to-size fit. If you need a very lightweight racer or a maximalist platform, other models will be a better match.

Pros & Cons

Pros

• Exceptional cushioning that feels plush underfoot and eases impact on long runs.
• GuideRails system provides noticeable lateral and medial stability without being intrusive.
• Breathable, flexible double jacquard knit upper balances comfort and durability.

Cons

• Some users find the toe box a bit narrow, so trying a size or width up may be necessary.

Specifications

Brand	Brooks
Model	Glycerin GTS 22
Support System	GuideRails holistic support
Cushioning	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit, breathable and accommodating
Use	Road running, cross training, gym, everyday wear
Special Certification	PDAC A5500 diabetic shoe

Our Verdict

The Brooks Glycerin GTS 22 is a smart choice for runners who want plush cushioning combined with meaningful stability. It offers a comfortable, protective ride for road miles and daily training, and its diabetic-friendly certification adds value for users needing an accommodating fit. Pick this shoe if cushioning and guided support are priorities; consider sizing options if you prefer extra room in the toe box.

Frequently Asked Questions

Are these shoes good for overpronation?
Yes, the GuideRails support system is designed to control excess motion and help keep the foot in a natural path.

Do they run true to size?
Fit is mixed; some buyers find them true to size while others note the toe box feels narrow, so trying on or ordering a half size up may help.

Can I use them for gym workouts as well as running?
Yes, the stable platform and cushioned midsole make them suitable for road runs, cross training, and general gym use.