Brooks Womens Glycerin GTS 22 Supportive Running Shoe (Style XS3K)

In this review of the Brooks Womens Glycerin GTS 22 Supportive Running Shoe the bottom line is clear: this shoe is for women who want plush cushioning with dependable stability for road running and everyday training. The standout reason to consider the Glycerin GTS 22 is its combination of DNA Tuned cushioning and the GuideRails support, which together deliver soft landings and controlled, smooth transitions without feeling overly rigid. It also carries a clinical certification for diabetic-friendly use, which adds confidence for buyers seeking foot-friendly features.

Key Features

• GuideRails support: Keeps excess motion at bay and helps stabilize the foot through heel-to-toe transitions for more confident road miles.
• DNA Tuned midsole: Larger heel cells create plush landings while smaller forefoot cells offer responsive toe-offs for energetic strides.
• Certified diabetic-friendly: The shoe is PDAC A5500 certified, indicating it meets standards for extra depth and therapeutic footwear needs.
• Accommodating knit upper: The new double jacquard knit delivers flexible fit and breathability while remaining durable for regular use.
• Broad platform: A wider base stabilizes the foot and smooths transitions, useful for both running and cross training.

Who It's For

The Glycerin GTS 22 is best for runners and active women who prioritize cushioning plus structural support - especially those who enjoy longer road runs, cross training at the gym, or want a stable daily trainer. It also suits shoppers who need a diabetic-friendly shoe with a cushioned ride and a roomy internal profile compared with highly minimal shoes.

Shoppers who prefer very narrow toe boxes or an extremely lightweight, minimalist racer might look elsewhere, as some users report the toe area can feel snug depending on foot shape, and the supportive elements add a bit of weight compared with neutral trainers.

Pros & Cons

Pros

• Exceptional cushioning that balances plush landings with responsive toe-offs for comfortable longs runs.
• Reliable support from GuideRails that controls excess motion without feeling intrusive.
• Durable, breathable upper that offers an accommodating fit for varied activities.
• Certified PDAC A5500 for diabetic-friendly footwear needs.

Cons

• Some users report a slightly narrow toe box, so those with very wide forefeet should try them on first.
• The supportive systems add modest weight compared with ultralight neutral trainers.

Specifications

Brand	Brooks
Model	Glycerin GTS 22
Support system	GuideRails holistic support
Midsole technology	DNA Tuned cushioning (dual-size cells)
Upper	Double jacquard knit, breathable and flexible
Certification	PDAC A5500 diabetic shoe
Predecessor	Glycerin GTS 21

Our Verdict

The Brooks Womens Glycerin GTS 22 is a strong choice for runners who want plush, plush cushioning with structural support for stable, smooth rides. Its combination of DNA Tuned midsole and GuideRails makes it a versatile trainer for road miles and gym sessions, and the PDAC certification is a meaningful plus for those who need foot-friendly features. Try them on if you have a wide forefoot, but otherwise this shoe is good value for supported comfort.

Frequently Asked Questions

Do these run true to size?
Fit varies by foot shape; many find true to size but some report the toe box can feel narrow, so try before you commit.

Are they good for long road runs?
Yes, the DNA Tuned cushioning and broad platform provide plush landings and stable transitions suited to longer road sessions.

Can they be used for cross training?
Yes, the supportive platform and breathable upper make them suitable for gym work and mixed training in addition to running.