Glycerin 22 for Men Neutral Running Shoe - Smooth Cushioning

Our review of the Glycerin 22 for Men finds it best for runners and walkers who prioritize plush comfort and smooth transitions. The single biggest reason to buy is the updated DNA Tuned midsole, which blends larger heel cells with smaller forefoot cells to deliver a soft landing and springy toe-off without sacrificing stability. As a certified PDAC A5500 diabetic shoe with the APMA Seal of Acceptance, it also stands out for foot health and everyday wearability rather than just speed-focused performance.

Key Features

• Neutral support: Provides maximal cushioning while maintaining a neutral ride suitable for road running and gym use.
• DNA Tuned cushion: Larger heel cells create plush landings and smaller forefoot cells produce more responsive toe-offs for smoother gait transitions.
• Accommodating fit: The double jacquard knit upper stretches and breathes to reduce pressure points while remaining durable.
• Smooth transitions: A broad platform and tuned heel-to-forefoot geometry help stabilize the foot during heel-to-toe movement.
• Health certifications: Certified PDAC A5500 and APMA accepted, making it a sensible option for diabetic and foot-care conscious buyers.

Who It's For

The Glycerin 22 is ideal for men seeking maximum daily cushioning for long walks, recovery runs, or extended standing periods; it suits neutral runners who want plush protection without extra pronation control. Runners who prioritize comfort over a responsive racing feel will appreciate the soft heel and cushioned platform.

Those who need firm medial support should look at the Glycerin GTS 22 instead, and runners wanting a very narrow racing fit or minimal ground feel may prefer lighter, lower-profile models. Fit opinions vary, so buyers with particularly narrow or very wide feet should try them on if possible.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that reduces impact during runs and walks.
• Stable, broad platform that improves confidence during heel-to-toe transitions.
• Breathable, durable double jacquard knit upper that accommodates different foot shapes.
• Certified PDAC A5500 and APMA seal, helpful for foot health concerns.

Cons

• Fit inconsistency: some customers find the shoe narrow while others find it suitable for wider feet, so sizing can be unpredictable.
• Not designed as a lightweight race shoe; it prioritizes plush cushioning over speed.

Specifications

Model	Glycerin 22
Support	Neutral
Cushioning Tech	DNA Tuned midsole
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21
Best use	Road running, walking, cross training, everyday wear

Our Verdict

The Glycerin 22 is a strong choice for men who want a plush, stable daily trainer with proven foot-health credentials. Its cushioned DNA Tuned midsole and broad platform make it excellent value for walkers and neutral runners who favor comfort and support over race-day lightness.

Frequently Asked Questions

Are these shoes good for walking?
Yes, customers consistently note excellent cushioning and comfort for walking and everyday wear.

Do they provide support for overpronation?
No, the Glycerin 22 is a neutral shoe; choose the Glycerin GTS 22 for added support.

How does sizing run?
Fit reports are mixed-some find them roomy while others find them narrow-so trying them on or checking return options is recommended.