Glycerin 22 Men Neutral Running Shoe - Maximum Plush Cushion

In this review the Glycerin 22 Men Neutral Running Shoe stands out as a top choice for runners and walkers who prioritize plush cushioning and smooth transitions. The single biggest reason to buy is its DNA Tuned midsole that blends larger heel cells with smaller forefoot cells to deliver soft landings and energetic toe-offs, making it ideal for longer road miles or extended periods on your feet. The shoe also carries medical endorsements that matter for comfort and foot health, which adds real-world value beyond typical running shoes.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel provide a soft, plush landing while smaller forefoot cells create a responsive toe-off for smoother gait cycles.
• Neutral Support: Designed for neutral runners, the shoe offers maximal cushioning without added corrective elements, suitable for road running and gym use.
• Accommodating Fit: A double jacquard knit upper delivers flexibility and breathability while accommodating wider feet comfortably.
• Smooth, Stable Transitions: A broad platform plus tuned heel and forefoot help stabilize the foot and smooth heel-to-toe movement.
• Medical Endorsements: Certified PDAC A5500 for diabetic use and awarded the APMA Seal of Acceptance, signaling suitability for sensitive or medical footwear needs.

Who It's For

The Glycerin 22 is best for men seeking a plush, neutral daily trainer for road running, long walking sessions, or cross training where cushioning and comfort are priorities. It suits those with flat or wide feet who need extra heel cushioning and a roomier knit upper without sacrificing responsiveness.

Runners who require heavy stability or motion control should look at supported variants instead, such as the Glycerin GTS 22, which keeps similar cushioning but adds corrective support. Budget shoppers sensitive to price may also compare less cushioned models for similar mileage at lower cost.

Pros & Cons

Pros

• Excellent plush cushioning that reduces impact on long runs or extended walking.
• Accommodating knit upper provides good fit for wider feet and breathability.
• Stable, smooth transitions thanks to a broad platform and tuned midsole geometry.

Cons

• Some buyers find the price high compared with lower-cushion alternatives, making value subjective.
• Customers disagree on fit and sizing, so trying on first is recommended.

Specifications

Our Verdict

The Glycerin 22 Men Neutral Running Shoe is a strong pick for runners and walkers who need maximum cushioning with smooth transitions and an accommodating fit. Its DNA Tuned midsole and medical endorsements make it especially attractive for those with sensitive feet or who log long miles, and it represents good value for anyone prioritizing comfort over minimal weight.

Frequently Asked Questions

Are these shoes good for wide feet?
The double jacquard knit upper is flexible and accommodating, and many customers report a comfortable fit for wider feet.

Do they provide support for flat feet?
They offer good cushioning and stability from a broad platform, which helps flat-footed walkers, but they are neutral shoes; consider the Glycerin GTS 22 for added support.

Should I size up or down?
Customers disagree on sizing, so trying them on or checking the store's return policy is recommended before committing.