Glycerin 22 Men Neutral Running Shoe - Plush, Smooth Ride

In this review the Glycerin 22 Men Neutral Running Shoe is presented as a top pick for runners and walkers who prioritize maximum cushioning and smooth transitions. The bottom line: this shoe is for men seeking a soft, well-cushioned road shoe that still offers responsive toe-offs thanks to Brooks DNA Tuned midsole technology. The Glycerin 22 earns its place for daily miles, gym sessions, and long walks, and it also carries PDAC A5500 diabetic certification and the APMA Seal of Acceptance for added foot health reassurance.

Key Features

• DNA Tuned Cushion: The midsole blends dual-size cells so the heel feels plush on landing while the forefoot returns energy for a responsive toe-off.
• Neutral Support: Delivers the maximum amount of cushioning without added stability hardware, making it suitable for neutral runners and everyday wear.
• Accommodating Fit: The double jacquard knit upper stretches for a comfortable fit that adapts to wider or fuller feet while remaining breathable.
• Smooth Transitions: A broad platform plus tuned heel and forefoot guide a stable, heel-to-toe roll that reduces abrupt motion during stride.
• Foot Health Certified: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance, offering extra confidence for users with specific foot care needs.

Who It's For

The Glycerin 22 is best for men who want a plush, cushioned road running shoe that also works for walking, cross training, and long days on their feet. It particularly suits those with neutral gait or flat feet looking for substantial heel cushioning and a roomy, accommodating upper.

Runners who need strong medial support or a corrective stability shoe should look elsewhere or consider the Glycerin GTS 22 for added support. Those seeking an ultralight race flat will find the Glycerin 22 heavier and optimized for comfort rather than speed.

Pros & Cons

Pros

• Exceptional heel cushioning and smooth ride thanks to the DNA Tuned midsole design.
• Comfortable, breathable knit upper that accommodates wider feet without pressure points.
• Certified PDAC A5500 and APMA accepted, adding credibility for diabetic foot care needs.

Cons

• With maximum cushioning the shoe feels less race-oriented and may be heavier than performance trainers.

Specifications

Model	Glycerin 22
Gender	Men
Support	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit for breathability and flexibility
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance

Our Verdict

The Glycerin 22 is a solid choice for men who value plush cushioning and a smooth, stable ride over speed. It offers an accommodating fit, reliable heel cushioning, and health-minded certifications that make it a good long-term investment for daily training, walking, and those who need extra foot protection.

Frequently Asked Questions

Are these shoes good for wide feet?
The double jacquard knit upper provides an accommodating fit that is often comfortable for wider feet.

Is this shoe suitable for diabetic foot care?
Yes, the Glycerin 22 is certified PDAC A5500 and has the APMA Seal of Acceptance, indicating it meets standards for diabetic foot health and podiatric acceptance.

Should I buy this for racing?
Not ideal for racing; the Glycerin 22 prioritizes maximum cushioning and comfort over lightweight performance, so it is better for training and walking.