Glycerin 22 Women Neutral Running Shoe - Plush, Smooth Ride

In this review the Glycerin 22 Women Neutral Running Shoe is presented as a high-cushion daily trainer best suited for runners and walkers who prioritize comfort and smooth transitions. The single biggest reason to buy is its DNA Tuned midsole that blends large heel cells with smaller forefoot cells to deliver a plush landing and a responsive toe-off, providing a noticeably softer ride than many neutral road shoes while still feeling energetic when pushing forward.

Key Features

• DNA Tuned Cushion: The midsole merges dual-size cells so the heel offers soft, plush landings while the forefoot returns energy for livelier toe-offs.
• Neutral Support: Built as a neutral shoe it provides maximum cushioning without added stability posts, ideal for natural gait road running.
• Certified Comfort: Certified PDAC A5500 diabetic shoe and APMA accepted, indicating an accommodating internal volume and supportive platform.
• Accommodating Fit: The double jacquard knit upper stretches where needed to reduce hot spots while maintaining breathability and durability.
• Smooth Transitions: A broad platform and tuned heel/forefoot design stabilize the foot and smooth heel-to-toe movement on pavement or the gym floor.

Who It's For

The Glycerin 22 is ideal for women who log long miles on roads, spend time walking or standing, or who want maximum cushioning without switching to a stability model; it answers those needs with a high-cushion neutral platform and an accommodating knit upper. Runners with knee or hip sensitivity who need extra shock absorption will likely find the soft heel and roomy toe box beneficial.

This is not aimed at people who require strong corrective support; athletes who overpronate heavily should consider a GTS or other stability option. Also, buyers who need a very narrow, race-day fit may prefer lighter, lower-cushion competition shoes rather than this plush trainer.

Pros & Cons

Pros

• Exceptional cushioning and soft heel feel for long runs and all-day comfort.
• Accommodating knit upper offers good breathability and a flexible fit.
• Broad platform and tuned midsole create smooth, stable transitions.
• Certified PDAC A5500 diabetic shoe and APMA Seal indicate thoughtful internal design.

Cons

• Sizing may be inconsistent for some buyers, with reports that certain pairs run small; try before committing if possible.
• As a plush neutral shoe, it lacks added support for severe overpronation.

Specifications

Our Verdict

The Glycerin 22 is a strong choice for women who want a soft, protective, and breathable neutral trainer that smooths transitions and soaks up impact. It represents good value for runners and walkers who prioritize cushioning and comfort over a race-flat profile, though anyone needing firm corrective support should look at a stability variant.

Frequently Asked Questions

Do these run true to size?
Some customers report a smaller fit on certain pairs, so measuring your foot or trying them on in store is recommended before buying.

Are these suitable for long runs?
Yes; the high level of cushioning and DNA Tuned midsole make them well suited to long road runs and extended walking.

Is this shoe good for people with foot sensitivity?
Yes; the diabetic shoe certification and accommodating fit make it a sensible option for people needing extra internal space and softer cushioning.