Glycerin 22 Womens Neutral Road Running Shoe - Plush Ride

Our review of the Glycerin 22 Womens Neutral Running Shoe concludes it is best for runners and walkers who prioritize maximum cushioning and smooth transitions. The single biggest reason to consider these shoes is the updated DNA Tuned cushion, which creates soft landings in the heel and a responsive toe-off in the forefoot, delivering a plush yet energetic ride. This model also carries both the APMA Seal of Acceptance and PDAC A5500 diabetic certification, which underscores its comfort and accommodative fit for sensitive feet.

Key Features

• Neutral support: Provides a neutral platform with the maximum amount of cushioning, making it suitable for road running and everyday wear without added stability posts.
• DNA Tuned cushion: Larger midsole cells in the heel offer soft landings while smaller forefoot cells support an energetic and smooth toe-off.
• Accommodating upper: The double jacquard knit upper stretches for a flexible fit and breathability while remaining durable for regular training.
• Smooth transitions: A broad platform combined with a tuned heel and forefoot stabilizes the foot and smooths heel-to-toe movement.
• Medical certifications: Certified PDAC A5500 for diabetic footwear and awarded the APMA Seal of Acceptance, signaling thoughtful design for foot health.

Who It's For

The Glycerin 22 is aimed at women who want plush cushioning for road runs, long walks, gym sessions, or cross training, especially those with knee or hip sensitivity who benefit from a soft, protective sole. Runners who enjoy a luxurious, squishy underfoot feel and a roomy toe box will appreciate the comfort and support described by many users.

Those who need firm stability or corrective support should look at support-specific models instead, such as versions with guide rails or built-in medial support. Also note that sizing reports vary; shoppers who typically fall between sizes may want to try them on or size carefully before committing.

Pros & Cons

Pros

• Exceptional cushioning and a plush ride thanks to the DNA Tuned midsole.
• Accommodating knit upper offers breathability and a comfortable fit for wider forefeet.
• Medical certifications (APMA and PDAC A5500) support suitability for sensitive feet.
• Stable broad platform contributes to smooth heel-to-toe transitions on roads.

Cons

• Sizing feedback is mixed, with some customers reporting they run smaller than expected, so fit can be inconsistent.
• Those seeking strong motion control or heavy support should consider a support-specific model.

Specifications

Model	Glycerin 22 Womens
Support type	Neutral
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Certifications	APMA Seal of Acceptance; PDAC A5500 diabetic shoe
Ideal use	Road running, cross training, gym, walking

Our Verdict

The Glycerin 22 is a strong choice for women who prioritize maximum cushioning and a smooth, stable ride for road runs and long-distance walking. With responsive DNA Tuned cushioning and a roomy, breathable upper, it offers clear value for anyone seeking comfort and foot health credentials, though those needing corrective support should pick a support-specific model.

Frequently Asked Questions

Do these run true to size?
Fit can vary; some users report the shoes run small, so try your usual size first and consider a half size up if between sizes.

Are they suitable for diabetic feet?
Yes, this model is certified PDAC A5500 and carries the APMA Seal of Acceptance, indicating it meets design criteria for sensitive feet.

What surfaces are best?
They are designed primarily for road running, walking, and gym use, where the cushioned platform and smooth transitions perform best.