Glycerin 22 Womens Neutral Running Shoe - Plush Neutral Cushioning

Our review of the Glycerin 22 womens neutral running shoe finds it best for runners and active walkers who want maximum cushioning without extra stability features. The single biggest reason to buy is the updated DNA Tuned cushion, which blends large heel cells for soft landings with smaller forefoot cells for more responsive toe-offs, delivering a smooth, comfortable ride on roads and treadmills. It also carries PDAC A5500 diabetic certification and the APMA Seal of Acceptance, so those needing an accommodating, health-minded fit will appreciate its design.

Key Features

• Neutral support: Provides neutral support with the maximum amount of cushioning, making it suitable for road running, gym work, and everyday walking.
• DNA Tuned cushion: Larger cells in the heel offer plush impact protection while smaller forefoot cells encourage energetic toe-offs for smoother transitions.
• Accommodating fit: The double jacquard knit upper stretches to reduce pressure points and improves breathability during longer sessions.
• Stable platform: A broad base stabilizes the foot and works with the tuned heel and forefoot to smooth heel-to-toe movement.
• Health certifications: Certified PDAC A5500 for diabetic use and granted the APMA Seal of Acceptance, supporting foot health considerations.

Who It's For

The Glycerin 22 is aimed at women seeking a plush, neutral running shoe for road miles, treadmill runs, cross training, and long periods on their feet. Runners who prioritize cushioning to protect knees and hips, or shoppers who need an accommodating toe box and a diabetic-certified option, will find the shoe especially appealing.

Those who want strong medial support or corrective stability should look elsewhere, such as Brooks models with GTS guidance. Also, buyers sensitive to precise sizing should try these on or check return policies, as some customers report variance in fit.

Pros & Cons

Pros

• Exceptional cushioning from DNA Tuned technology for soft landings and responsive toe-offs.
• Comfortable, roomy fit with a breathable double jacquard knit upper that reduces pressure on the foot.
• Health-focused credentials with PDAC A5500 diabetic certification and the APMA Seal of Acceptance.
• Stable broad platform that supports smooth heel-to-toe transitions during varied activities.

Cons

• Sizing can be inconsistent among wearers, with some reporting they run smaller than expected.
• Maximum cushioning may feel bulky to runners who prefer a minimal or highly responsive race shoe.

Specifications

Model	Glycerin 22
Gender	Womens
Support type	Neutral
Cushion technology	DNA Tuned with dual-size midsole cells
Upper	Double jacquard knit
Health certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Glycerin 22 is a strong pick for women who want plush cushioning and a forgiving, breathable fit for road running, gym use, or long days on their feet. Its DNA Tuned midsole and health certifications add tangible value for those prioritizing comfort and foot health, though shoppers should confirm sizing before committing.

Frequently Asked Questions

Are these shoes good for long walks?
Yes, customers report excellent cushioning and support for extended walking and daily wear.

Do they provide stability for overpronation?
No, the Glycerin 22 is a neutral shoe; runners needing extra support should consider a GTS model.

Are they suitable for diabetic feet?
Yes, this model is certified PDAC A5500 and has the APMA Seal of Acceptance, indicating an accommodating design for foot health.