Glycerin GTS 22 Womens Running Shoe - Supportive Cushioning

Our review of the Glycerin GTS 22 Womens Running Shoe finds it best for road runners and gym users who prioritize plush cushioning without losing guidance for natural motion. The single biggest reason to buy is the combination of Brooks' DNA Tuned cushion for soft landings and responsive toe-offs plus the GuideRails support system that keeps excess motion in check, making long miles and daily training more comfortable and stable.

Key Features

• GuideRails support: Helps stabilize the foot by limiting excessive lateral motion, which reduces strain during long runs and cross training sessions.
• DNA Tuned cushion: Larger heel cells provide plush landings while smaller forefoot cells deliver a responsive toe-off for smoother transitions.
• Accommodating fit: The double jacquard knit upper stretches to the foot for breathable comfort while remaining durable for repeated use.
• Stable platform: A broad base and tuned heel create smooth heel-to-toe transitions and improved balance on road surfaces.
• Certified diabetic friendly: The shoe is a PDAC A5500 certified diabetic shoe, offering an option for customers needing medical footwear features.

Who It's For

The Glycerin GTS 22 is aimed at women who want a high-cushion daily trainer that still offers structure - ideal for road runners who want a plush ride combined with guidance, gym-goers who value stability during cross training, and anyone who needs a shoe cleared for diabetic foot care. The blend of cushioning and support suits longer easy runs, recovery miles, and everyday wear.

Runners who prefer a very wide toe box or are strictly minimalists should look elsewhere; some customers reported the toe box feels narrow for their foot shape. Those who want a lighter, less protective shoe for speedwork may prefer a less cushioned, more responsive racing model.

Pros & Cons

Pros

• Generous, plush cushioning from DNA Tuned technology gives soft landings and energetic toe-offs.
• GuideRails support provides noticeable stabilization without feeling overly rigid.
• Breathable and flexible double jacquard knit upper offers an accommodating fit and durability.

Cons

• Some users find the toe box narrow, so fit can vary and may require trying a half size up.

Specifications

Our Verdict

The Glycerin GTS 22 Womens Running Shoe is a strong choice for runners and active women who want plush cushioning paired with meaningful support. Its combination of DNA Tuned cushioning and GuideRails makes it a versatile daily trainer that also fits diabetic footwear needs, offering good value for those who prioritize comfort and stability over a minimalist ride.

Frequently Asked Questions

Are these shoes good for long runs?
Yes, the plush midsole and stable platform make them well suited for long, easy miles and recovery runs.

Do they provide arch support?
The GuideRails system helps control excess motion and supports the arch indirectly; many customers report improved support and comfort.

Should I size up for width?
If you have a wide forefoot or prefer extra toe room, consider trying a half size up as some users found the toe box narrow.