Glycerin GTS 22 Womens Supportive Running Shoe - Cushioned Ride

Our review of the Glycerin GTS 22 womens shoe finds it best for runners and gym goers who want plush cushioning with purposeful support. The single biggest reason to buy is the combination of Brooks DNA Tuned midsole and GuideRails support, which delivers soft landings and controlled, smooth transitions without feeling bulky. Reviewers consistently praise the comfort and relief from foot pain, and the GTS 22 feels especially steady on road runs and everyday training where stabilization and a forgiving ride matter most.

Key Features

• GuideRails support: Keeps excess motion in check so the foot tracks in a natural path for steadier runs and less fatigue.
• DNA Tuned cushion: Larger heel cells provide plush landings while smaller forefoot cells offer responsive toe-offs for balanced energy return.
• Accommodating knit upper: Double jacquard knit gives a flexible, breathable fit that adapts to the foot without feeling restrictive.
• Stable platform: A broad base stabilizes the foot and helps smooth heel-to-toe transitions during longer runs or cross training.
• Diabetic certified: Certified PDAC A5500, making it a suitable option for walkers who need extra foot protection and comfort.

Who It's For

The Glycerin GTS 22 is ideal for women who want a plush yet supported shoe for road running, gym sessions, and daily wear. Runners who appreciate a soft heel strike and a guided midfoot will value the DNA Tuned cushioning combined with the GuideRails system, especially if they have occasional overpronation or want extra stability.

Those seeking an extremely narrow racing shoe or minimal barefoot feel should look elsewhere, as this model favors cushioning and structure over a minimal profile. Also, if an ultra-wide toe box is essential, try them on first since customers report mixed fit experiences in the forefoot.

Pros & Cons

Pros

• Exceptional comfort and arch support that many users say relieves foot pain.
• Balanced cushioning from DNA Tuned that softens landings and aids toe-offs.
• GuideRails provide reliable stability without feeling overly rigid.
• Breathable double jacquard knit upper for a flexible, accommodating fit.

Cons

• Fit can be mixed for some customers, with a toe box that feels roomy to some and narrow to others.
• Heavier than minimalist trainers, so not ideal for race-day speed work.

Specifications

Brand	Brooks
Model	Glycerin GTS 22
Gender	Womens
Cushioning	DNA Tuned midsole with dual-size cells
Support System	GuideRails holistic support
Upper	Double jacquard knit
Certification	PDAC A5500 diabetic certified

Our Verdict

The Glycerin GTS 22 is a strong choice for women who prioritize plush cushioning and stable support on the road and in the gym. Its DNA Tuned midsole and GuideRails make it especially valuable for anyone seeking pain relief and steadier gait mechanics, offering good value for runners who want comfort paired with thoughtful stability.

Frequently Asked Questions

Are these good for overpronation?
Yes, the GuideRails support helps control excess motion and can benefit mild to moderate overpronation.

Do they run true to size?
Fit is mixed in customer feedback; try your usual size but consider trying them on if you have a very wide or very narrow forefoot.

Can I use them for the gym as well as running?
Yes, the stable platform and cushioned ride make them suitable for road running, cross training, and general gym use.