Glycerin GTS 22 Womens Supportive Running Shoe - Plush GuideRails

Our review of the Glycerin GTS 22 womens running shoe finds it best for runners who want plush cushioning with built-in stability. This shoe stands out because its DNA Tuned midsole blends larger heel cells and smaller forefoot cells to deliver soft landings and responsive toe-offs, while the GuideRails support keeps excess motion in check for a smoother, more controlled ride. Overall it is a supportive, comfortable daily trainer that balances cushioning and stability without feeling overly rigid.

Key Features

• GuideRails support: Keeps excess motion at bay to help stabilize the foot and protect knees and hips during runs or gym work.
• DNA Tuned cushion: Larger heel cells provide plush landings while smaller forefoot cells promote energetic and responsive toe-offs.
• Accommodating fit: The double jacquard knit upper flexes with the foot for breathable, durable comfort across long outings.
• Smooth transitions: A broad platform and tuned heel-to-forefoot geometry produce steady, heel-to-toe roll for road running.
• Certified diabetic option: The shoe is PDAC A5500 certified, making it suitable for users needing accommodative diabetic footwear.

Who It's For

The Glycerin GTS 22 is ideal for female runners who prioritize comfort and stability on daily runs, road miles, or mixed gym sessions. It works well for runners who appreciate extra cushioning but still want a responsive toe-off, and for anyone seeking an accommodating, breathable upper with reliable support.

Runners who prefer an ultra-wide toe box or a minimalist, barefoot feel should look elsewhere; some wearers report a slightly narrower toe area. Also, if you need a racing-flat pace shoe, the plush platform here is better suited to training and recovery runs than tempo race days.

Pros & Cons

Pros

• Excellent cushioning and energy return from the DNA Tuned midsole.
• GuideRails system provides noticeable medial-lateral control for stable strides.
• Comfortable, breathable double jacquard knit upper that adapts to the foot.

Cons

• Some users find the toe box on the narrower side, so width-sensitive fitters may need to try before buying.

Specifications

Model	Glycerin GTS 22
Gender	Womens
Support system	GuideRails holistic support
Cushioning	DNA Tuned midsole (larger heel/smaller forefoot cells)
Upper	Double jacquard knit, breathable and durable
Use case	Road running, cross training, gym
Certification	PDAC A5500 diabetic shoe

Our Verdict

The Glycerin GTS 22 is a strong choice for women who want a plush, supportive daily trainer that tames excess motion without sacrificing cushioning. Its GuideRails stability and tuned cushioning make it especially good value for runners after comfort, support, and a breathable fit for regular road miles and gym sessions.

Frequently Asked Questions

Do these shoes run true to size?
Fit reports are mixed; many find length true to size but some say the toe box feels narrow, so try on if you need extra forefoot room.

Are they good for diabetic feet?
Yes, the model is PDAC A5500 certified, indicating it meets standards for accommodative diabetic footwear.

Can I use them for speed work?
They are best as a daily trainer and for recovery runs; the plush platform is less suited to lightweight race-pace sessions.