Glycerin GTS 22 Womens Supportive Running Shoe - Smooth Cushion

In this review of the Glycerin GTS 22 womens running shoe, the bottom line is simple: this shoe is for runners who want plush cushioning combined with stability for longer road miles and daily workouts. The standout reason to consider it is the combination of Brooks' DNA Tuned cushioning and the GuideRails support, which deliver soft landings and controlled motion without feeling bulky. Reviewers frequently call out comfort and support as the primary benefits, making it a sensible choice for those prioritizing cushioning and midfoot-to-forefoot transitions.

Key Features

• GuideRails support: Keeps excess motion in check by guiding the foot along its natural path to reduce strain and improve stability during runs or gym sessions.
• DNA Tuned midsole: Larger heel cells and smaller forefoot cells provide plush landings and responsive toe-offs for smoother transitions.
• Accommodating knit upper: A double jacquard knit balances flexibility and breathability to adapt to the foot while remaining durable for regular use.
• Broad platform: A wider base helps stabilize the foot through heel-to-toe movement so transitions feel balanced and secure.
• Certified diabetic-friendly: The shoe is PDAC A5500 certified, indicating it meets standards for diabetic footwear needs related to fit and protection.

Who It's For

The Glycerin GTS 22 is best for women who run on roads, do cross training, or spend time in the gym and need a cushioning-first shoe that still offers structure. Runners who benefit from arch support or want a shoe that reduces excess pronation will appreciate the GuideRails system and the stable platform.

Those who prefer minimal, race-day shoes or need a very wide toe box may want to try a different model; some customers note the toe box can feel narrow. If you prioritize a firmer, performance-oriented ride over plush cushioning, look at lighter stability trainers instead.

Pros & Cons

Pros

• Exceptional cushioning that many describe as life-changing for long runs and everyday wear.
• Integrated GuideRails provide noticeable support without heavy corrective feeling.
• Durable, breathable knit upper that adapts to the foot while maintaining structure.

Cons

• Some users report the toe box runs narrow, so fit may be inconsistent for wider-footed runners.

Specifications

Model	Glycerin GTS 22
Intended use	Road running, cross training, gym
Support system	GuideRails holistic support
Midsole technology	DNA Tuned dual-size cells
Upper	Double jacquard knit
Certification	PDAC A5500 diabetic shoe

Our Verdict

The Glycerin GTS 22 is a strong choice for women seeking a cushioned, stable trainer that handles daily miles and mixed workouts with comfort. Its combination of plush DNA Tuned cushioning and GuideRails support makes it a worthwhile pick for runners who value protective, stable cushioning and durability over lightweight race performance.

Frequently Asked Questions

Are these shoes good for long road runs?
The plush midsole and stabilizing platform make them well suited for longer road miles and recovery runs.

Do they provide pronation control?
Yes, the GuideRails system limits excess motion and offers supportive guidance without rigid correction.

How does the fit run?
Fit can vary; many find the shoe comfortable, but some users report the toe box feels narrow so try sizing or widths if you have a wide forefoot.