Glycerin GTS 22 Womens Supportive Running Shoe - Stable Cushion

In this review we look at the Brooks Glycerin GTS 22 Womens Supportive Running Shoe and why it stands out for runners who want plush cushioning without sacrificing stability. The single biggest reason to consider these shoes is the combination of Brooks DNA Tuned midsole and GuideRails support, which delivers luxurious landings and guided motion control for smoother transitions. Overall the Glycerin GTS 22 is best for road runners and gym users seeking comfort, generous cushioning, and a stable platform for daily miles.

Key Features

• GuideRails support: Keeps excess motion at bay so runners experience more stable, controlled strides during long runs or varied workouts.
• DNA Tuned cushion: Dual-size midsole cells give plush heel landings and responsive toe-offs for balanced comfort and energy return.
• Accommodating fit: The double jacquard knit upper flexes with the foot while remaining breathable and durable through extended use.
• Smooth transitions: A broad platform with a tuned heel and forefoot promotes stable heel-to-toe roll for consistent road running feel.
• Diabetic-friendly certification: Certified PDAC A5500 status indicates suitability for wearers who need an accommodating, medical-grade fit.

Who It's For

The Glycerin GTS 22 is tailored to women who prioritize cushioning and stability: road runners logging regular miles, cross trainers who need supportive footwear for mixed sessions, and anyone seeking a comfortable daily trainer with guided support. The shoe's broad platform and GuideRails make it a strong choice for runners with mild pronation who want control without a hard motion-correction feel.

Those who prefer a very roomy toe box or a narrow, race-oriented shoe should look elsewhere; some users report the forefoot fits snugly. If you want a minimal, lightweight racer for speedwork, a lighter neutral trainer would be more appropriate than this plush, supportive model.

Pros & Cons

Pros

• Exceptional cushioning that feels plush underfoot for longer runs.
• GuideRails system provides noticeable support and reduces excess motion.
• Breathable double jacquard knit upper offers an accommodating fit for many foot shapes.
• Certified PDAC A5500 for diabetic-friendly wear adds practical value.

Cons

• Some wearers find the toe box a bit narrow, so fit can vary by foot shape.
• Heavier and less race-oriented than lightweight trainers, which may not suit speed-focused runners.

Specifications

Our Verdict

The Glycerin GTS 22 Womens shoe is a compelling pick for runners who want plush, reliable cushioning paired with structured support. Its DNA Tuned midsole and GuideRails deliver comfortable landings and controlled motion, making it good value for daily mileage and mixed workouts. Buy these if you need stability without a clinical feel; look elsewhere if you need a very wide toe box or a lightweight racing shoe.

Frequently Asked Questions

Are these shoes good for people with mild overpronation?
Yes. The GuideRails support is designed to keep excess motion in check and works well for mild overpronation while remaining comfortable.

Do they run true to size?
Fit varies: some customers find them true to size while others note a snug toe box, so trying your usual size or a half size up is advisable if you have a wider forefoot.

Can I use these for gym workouts as well as running?
Yes. The stable platform and cushioning make them suitable for road running, cross training, and general gym use.