Men's Glycerin 22 Neutral Running Shoe - Maximum Cushioning

In this review of the Men's Glycerin 22 Neutral Running Shoe the bottom line is simple: this shoe is for runners and walkers who want plush, protected landings with smooth forward motion. The standout is Brooks' DNA Tuned midsole, which blends dual-size cells to create very soft heel cushioning and a more responsive forefoot for toe-offs. The shoe also carries the APMA Seal of Acceptance and is a certified PDAC A5500 diabetic shoe, making it a sensible option for anyone prioritizing cushioning, comfort, and foot health rather than aggressive stability or minimal feel.

Key Features

• DNA Tuned Cushion: Larger cells in the heel deliver soft, plush landings while smaller forefoot cells provide a livelier toe-off for a balanced ride.
• Neutral Support: Designed as a neutral trainer, it offers the maximum amount of cushioning without adding corrective support, ideal for natural gait patterns.
• Accommodating Fit: The double jacquard knit upper stretches where needed to reduce hot spots and improve breathability for longer wear.
• Smooth Transitions: A broad platform combined with a tuned heel and forefoot smooths heel-to-toe motion for consistent road running and walking.
• Health Certifications: Certified PDAC A5500 and APMA-accepted, indicating suitability for users who need extra foot protection and clinical recognition.

Who It's For

The Glycerin 22 is best for road runners and regular walkers who prioritize plush cushioning and a stable platform over firm responsiveness. It works well for cross training, gym sessions, and everyday wear when comfort and a soft ride are the main goals.

Runners seeking strong corrective support should look at the Glycerin GTS 22 instead, while those wanting a minimal, highly responsive race shoe should consider lighter, firmer models. Also, shoppers who need a guaranteed wide fit should try on this model first, as customer feedback on width and sizing is mixed.

Pros & Cons

Pros

• Exceptional cushioning in the heel and forefoot for pain-free runs and long walks.
• Comfortable, breathable double jacquard knit upper that adapts to the foot.
• Broad platform and tuned midsole provide smooth, stable transitions.
• APMA Seal and PDAC A5500 certification add confidence for users with foot health concerns.

Cons

• Fit is inconsistent across users; some find the shoe narrow while others report a comfortable fit for wider feet.
• Heavily cushioned feel may be too soft for runners who prefer a firm, highly responsive shoe.

Specifications

Model	Glycerin 22
Support	Neutral
Midsole Technology	DNA Tuned dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Men's Glycerin 22 is a strong choice for runners and walkers who want maximal cushioning, smooth transitions, and validated foot-health credentials. It represents good value for those prioritizing comfort and protection, though shoppers should try them for fit due to mixed reports on width and sizing.

Frequently Asked Questions

Are these shoes good for long-distance running?
Yes; the plush heel cushioning and smooth transitions make them suitable for long road runs where comfort is a priority.

Do they offer support for overpronation?
No; the Glycerin 22 is a neutral shoe-choose the Glycerin GTS 22 for built-in support features.

How do they fit compared with previous Glycerin models?
They retain the soft, cushioned character of the Glycerin 21 but with a newly engineered knit upper; however, fit can vary so trying them on is recommended.