Mens Glycerin 22 Neutral Running Shoe - Plush, Smooth Ride

In this review of the Mens Glycerin 22 Neutral Running Shoe the bottom line is simple: this is a plush, highly cushioned neutral trainer best suited to runners and walkers who prioritize comfort and smooth transitions. The shoe stands out for its DNA Tuned midsole that blends larger heel cells with smaller forefoot cells for soft landings and responsive toe-offs, and it carries both PDAC A5500 diabetic certification and the APMA Seal of Acceptance. Overall it is a top pick for anyone wanting maximum cushioning without extra stability hardware.

Key Features

• DNA Tuned Cushion: Larger heel cells and smaller forefoot cells create soft, plush landings and snappy toe-offs for a balanced ride.
• Neutral Support: Designed as a neutral shoe, it delivers maximum cushioning without added corrective support so it suits a broad range of runners and walkers.
• Accommodating Fit: The double jacquard knit upper flexes with the foot for breathable comfort and an adaptive feel during longer sessions.
• Smooth Transitions: A broad platform plus a tuned heel and forefoot help stabilize the foot and promote smooth heel-to-toe motion.
• Medical-Friendly Design: Certified PDAC A5500 for diabetic use and granted the APMA Seal of Acceptance, offering reassurance for foot health needs.

Who It's For

The Glycerin 22 is ideal for men who want maximum cushioning for road running, long walking sessions, cross training, or everyday wear. Riders who value a plush ride and smooth transitions-rather than firm responsiveness or strong motion control-will appreciate the DNA Tuned midsole and broad platform.

Runners who need strong stability or corrective support should look at support-specific models such as the Glycerin GTS lineup. Also, those seeking a very narrow race-day racer or minimal shoe will find this model too soft and substantial for speed-focused sessions.

Pros & Cons

Pros

• Exceptional cushioning and comfortable heel padding make long runs and walks easy on the feet.
• Certified PDAC A5500 and APMA accepted, suitable for users with specific foot health concerns.
• Breathable, flexible double jacquard knit upper offers an accommodating fit and good airflow.
• Stable broad platform and tuned transitions reduce abrupt heel-to-toe shifts.

Cons

• Fit is inconsistent among users; some find it narrow while others say it suits wide feet, so trying on first is recommended.
• Maximum cushioning adds weight and bulk compared with lighter, performance-focused trainers.

Specifications

Model	Glycerin 22
Support type	Neutral
Cushioning tech	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit
Health certifications	PDAC A5500 certified; APMA Seal of Acceptance
Predecessor	Glycerin 21

Our Verdict

The Mens Glycerin 22 is a strong choice for runners and walkers who want plush cushioning, smooth transitions, and medical-minded design features. It offers good value for anyone prioritizing comfort and foot health, though shoppers sensitive to fit or seeking a lighter, speedier shoe should compare sizes and alternatives first.

Frequently Asked Questions

Are these shoes suitable for diabetic feet?
Yes, the Glycerin 22 is PDAC A5500 certified and carries the APMA Seal of Acceptance, indicating suitability for diabetic and foot-health considerations.

Do these run true to size?
Customers disagree on sizing; some find a true fit while others say they run narrow or wide, so trying them on or ordering from a retailer with an easy return policy is advised.

Is this shoe good for long runs?
The substantial cushioning and stable platform make it well suited to long runs and extended walking where comfort and smooth transitions are priorities.