Womens Glycerin 22 Neutral Running Shoe - Cushioned Road Trainer

In this review of the Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: this shoe is for runners and active walkers who want maximum plush cushioning without extra stability hardware. The review finds the Glycerin 22 delivers a soft, protective ride thanks to Brooks DNA Tuned midsole cells that give a noticeably cushioned heel and a responsive forefoot. Certified as a PDAC A5500 diabetic shoe and carrying the APMA Seal of Acceptance, it also suits people who need an accommodating, breathable fit and reliable support for long days on hard surfaces.

Key Features

• DNA Tuned Cushion: Larger heel cells create soft, plush landings while smaller forefoot cells encourage energetic toe-offs for smoother transitions.
• Neutral Support: Designed as a neutral shoe, it offers the maximum amount of cushioning without added corrective support, ideal for natural gait patterns.
• Accommodating Fit: The double jacquard knit upper stretches where needed and breathes well, providing a roomy toe box and durable coverage.
• Smooth, Stable Transitions: A broad platform and tuned heel and forefoot stabilize each step and reduce abrupt heel-to-toe shifts.
• Medical Certifications: Certified PDAC A5500 for diabetic accommodation and granted the APMA Seal of Acceptance, giving extra confidence for foot health.

Who It's For

The Glycerin 22 is best for neutral road runners, daily walkers, and people who prioritize plush cushioning and foot comfort over motion control. It performs well for gym sessions, cross training, and long periods on pavement where cushioning and a roomy toe box reduce foot fatigue.

Runners who need firm corrective support or a strong stability platform should look elsewhere or consider the Glycerin GTS version for added guidance. Also, shoppers who prefer a very snug, performance race fit may find this model too soft and roomy for speedy tempos.

Pros & Cons

Pros

• Exceptional cushioning with a soft, squishy midsole that eases impact on knees and hips.
• Comfortable, breathable knit upper that accommodates wider feet and long walks without hot spots.
• Medical certifications provide reassurance for users with diabetic foot concerns or who value podiatric approval.
• Stable, broad platform helps carry the foot through a smooth heel-to-toe transition.

Cons

• Sizing appears inconsistent to some buyers; a try-on or careful measuring is recommended before purchase.
• Those seeking strong corrective support or a race-focused fit may find the cushioning too soft for aggressive training.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size midsole cells
Upper	Double jacquard knit, breathable and accommodating
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Ideal Uses	Road running, cross training, gym, long-distance walking

Our Verdict

The Womens Glycerin 22 is a strong choice for people who value plush cushioning and a forgiving, breathable fit for everyday miles and long walks. Its medical certifications and soft, stable ride make it a sensible investment for comfort and foot health, though shoppers who need firm stability or a race-ready fit should consider other models.

Frequently Asked Questions

Are these shoes good for long walking sessions?
Yes, the Glycerin 22s are well cushioned with a roomy toe box and supportive platform that many customers found comfortable for long distances.

Do they provide stability for overpronation?
No, this is a neutral shoe; those needing additional support should choose the Glycerin GTS or a stability-specific model.

Should I size up or down?
Customers report mixed sizing feedback, so it is wise to try them on or follow the brand size chart before buying.