Womens Glycerin 22 Neutral Running Shoe - Max Cushion Comfort

In this review of the Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: these are a top choice for runners and walkers who want maximum cushioning without added corrective structure. The Glycerin 22 stands out because its DNA Tuned cushion blends larger heel cells and smaller forefoot cells to deliver soft landings and responsive toe-offs, making it ideal for long miles or all-day wear. It is also certified as a PDAC A5500 diabetic shoe and holds the APMA Seal of Acceptance, which will matter to anyone seeking protective, foot-friendly footwear.

Key Features

• Neutral Support: Provides a neutral platform with the most cushioning in the Brooks lineup for plush comfort on road runs and in the gym.
• DNA Tuned Cushion: Larger midsole cells at the heel create soft landings while smaller forefoot cells encourage energetic toe-offs.
• Accommodating Fit: The double jacquard knit upper flexes to the foot and adds breathability without feeling restrictive during long sessions.
• Smooth Transitions: A broad platform plus a tuned heel and forefoot stabilize the foot and smooth heel-to-toe movement.
• Medical Certifications: Certified PDAC A5500 and awarded the APMA Seal of Acceptance, supporting use by people needing protective footwear.

Who It's For

The Glycerin 22 is aimed at women seeking maximal cushioning with a neutral ride: long-distance road runners who prize comfort, walkers who need protective footwear for extended use, and gym goers who prefer a soft, stable base. The medical certifications also make it a sensible pick for customers requiring a diabetic-friendly shoe that still performs for exercise.

Those who need firm stability or motion control should consider a support-specific model instead, such as Brooks options with added guidance features. Additionally, shoppers seeking a very narrow race-flat feel or minimal cushioning should look elsewhere; the Glycerin 22 is built around plush cushioning rather than low-profile speed.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that reduces impact on knees and hips for long wear.
• Accommodating knit upper offers roomy toe box and breathable fit that adapts to foot shape.
• Stable, broad platform and tuned transitions help maintain a smooth gait.
• Certified PDAC A5500 and APMA accepted, backing its protective and health-minded design.

Cons

• Sizing reports vary and some users find the fit runs small, so trying before committing is recommended.
• Maximal cushioning can feel bulky to runners who prefer a lighter, minimalist shoe.

Specifications

Model	Glycerin 22
Support Type	Neutral
Cushion Technology	DNA Tuned midsole
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 diabetic shoe, APMA Seal of Acceptance
Ideal Uses	Road running, cross training, walking, gym

Our Verdict

The Womens Glycerin 22 is a compelling choice for women who prioritize plush cushioning and a smooth, neutral ride. Its DNA Tuned midsole and accommodating knit upper deliver comfort and support for long runs, daily walking, or standing work, and the medical certifications add practical value. If cushioning and foot protection are your top priorities, this shoe offers a strong balance of comfort and stability.

Frequently Asked Questions

Do these run true to size?
Reports vary and some customers find the sizing small, so sizing up may be necessary for those between sizes or with wider feet.

Is this shoe good for diabetic foot care?
Yes, the Glycerin 22 is a certified PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, indicating suitability for protective use.

Is it suitable for stability needs?
It is a neutral shoe with a broad platform for stability, but runners needing corrective support should choose a GTS or dedicated stability model.