Womens Glycerin 22 Neutral Running Shoe - Max Cushioned Ride

Our review of the Womens Glycerin 22 Neutral Running Shoe finds it best suited to runners and walkers who prioritize plush cushioning and smooth transitions. The single biggest reason to buy is the updated DNA Tuned midsole that blends larger heel cells with smaller forefoot cells to deliver soft landings and energetic toe-offs, producing a noticeably cushioned yet responsive feel. It is also certified as a PDAC A5500 Diabetic shoe and carries the APMA Seal of Acceptance, which makes it a compelling option for anyone seeking comfort plus medical-minded design.

Key Features

• DNA Tuned Cushion: Larger cells in the heel provide soft, plush landings while smaller forefoot cells invite more responsive toe-offs for steady forward motion.
• Neutral Support: Designed for neutral runners, the shoe offers the maximum level of cushioning without added stability posts, making it versatile for road runs, the gym, or cross training.
• Accommodating Fit: The double jacquard knit upper flexes and breathes while offering a roomy toe box that reduces pressure on toes during long walks or runs.
• Smooth Transitions: A broad platform and tuned heel and forefoot work together to stabilize the foot and smooth heel-to-toe transitions.
• Medical Certifications: Certified PDAC A5500 as a diabetic shoe and granted the APMA Seal of Acceptance, signaling attention to foot health and orthotic compatibility.

Who It's For

The Womens Glycerin 22 is ideal for neutral road runners who prefer a plush, cushioned ride and for walkers or gym users who need long-lasting comfort across varied activities. The shoe suits those with sensitive feet or mild foot health concerns since it is PDAC A5500 certified and APMA-accepted, meaning it accommodates orthotics and prioritizes foot comfort.

Runners who need strong corrective support or motion control should look elsewhere or consider the Glycerin GTS 22 for added support. Also, buyers who require a very narrow fit should be cautious, as some users report sizing differences and the knit upper favors a more accommodating, roomier shape.

Pros & Cons

Pros

• Plush cushioning with balanced responsiveness from the DNA Tuned midsole.
• Comfortable, breathable double jacquard knit upper that reduces pressure in the toe box.
• Stable platform and tuned transitions that make heel-to-toe running feel smooth.
• Certified PDAC A5500 diabetic shoe and APMA Seal, supporting foot health and orthotic use.

Cons

• Some customers report inconsistent sizing and a fit that can feel small to certain feet.
• Neutral design may not provide enough support for overpronators without opting for the GTS variant.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned dual-cell cushioning
Upper	Double jacquard knit, breathable and flexible
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Predecessor	Glycerin 21
Best For	Road running, walking, cross training, gym use

Our Verdict

The Womens Glycerin 22 is a strong choice for runners and walkers who want maximum cushioning paired with a responsive toe-off and an accommodating fit. Its medical certifications and smooth transitions make it good value for those who prioritize foot comfort and long miles; choose the GTS variant only if you need extra stability.

Frequently Asked Questions

Are these shoes suitable for orthotics?
The Glycerin 22 is PDAC A5500 certified and accommodates orthotics, so it is appropriate for many users who need inserts.

Do they run true to size?
Customers report mixed sizing impressions; the knit upper is roomy but some users find them small, so try your usual size and be prepared to exchange if needed.

Is this model good for daily long walks?
Yes, the plush DNA Tuned cushion and broad platform make the shoe comfortable for long walks and extended wear.