Womens Glycerin 22 Neutral Running Shoe - Maximum Cushion

In this review of the Womens Glycerin 22 Neutral Running Shoe the bottom line is simple: these are for runners and walkers who prioritize plush cushioning and smooth transitions. The shoe stands out because of Brooks' DNA Tuned midsole, which blends larger heel cells for soft landings with smaller forefoot cells for responsive toe-offs, delivering a noticeably cushioned yet energetic ride. It also carries the PDAC A5500 diabetic certification and the APMA Seal of Acceptance, making it a solid choice for anyone needing an accommodating, health-minded everyday running shoe.

Key Features

• DNA Tuned Cushion: A midsole design that uses larger cells in the heel and smaller cells in the forefoot to balance soft landings with lively toe-offs for smoother runs.
• Neutral Support: Provides neutral stability while maximizing cushioning, suitable for road running, cross training, and gym sessions without added motion control.
• Accommodating Fit: The double jacquard knit upper flexes to the foot and improves breathability while maintaining durability for longer wear.
• Smooth Transitions: A broad platform combined with a tuned heel and forefoot helps stabilize the foot and ease heel-to-toe movement.
• Health Certifications: Certified PDAC A5500 for diabetic-friendly fit and granted the APMA Seal of Acceptance, which supports foot health considerations.

Who It's For

The Glycerin 22 is best for neutral runners who want maximum cushioning without additional support features, and for anyone who spends long periods on their feet and values a soft, supportive ride. Road runners, gym-goers, and walkers who need a roomy toe box and plush midsole will appreciate the comfort-first setup.

Those who need pronounced stability or corrective motion control should look at guided-stability models instead, such as the Glycerin GTS line. Also, buyers who rely on very exact sizing should be cautious: customer feedback shows some disagreement on fit, so trying on or checking return options is recommended.

Pros & Cons

Pros

• Exceptionally cushioned feel from the DNA Tuned midsole that reduces impact on knees and hips.
• Roomy toe box and breathable double jacquard knit upper for comfort on long walks or runs.
• Certified PDAC A5500 and APMA Seal of Acceptance, which supports diabetic-friendly and podiatric approval.

Cons

• Sizing consistency varies among customers, with some reporting the shoes run small, so fit may require trying different sizes.

Specifications

Model	Glycerin 22
Support Type	Neutral
Midsole Technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Ideal Use	Road running, cross training, gym, walking

Our Verdict

The Womens Glycerin 22 is a strong pick for neutral runners and anyone who prioritizes plush cushioning and a comfortable, accommodating fit. Its DNA Tuned midsole and health-focused certifications add real value for daily training and long hours on foot, though shoppers should verify sizing before committing.

Frequently Asked Questions

Are these shoes good for long-distance walking?
Yes, the plush midsole and roomy toe box make them comfortable for long walks and extended periods on your feet.

Do these provide motion control for overpronation?
No, the Glycerin 22 is a neutral shoe; runners needing extra support should consider a guided-stability model.

Are they suitable for diabetic feet?
Yes, the shoe is PDAC A5500 certified and carries the APMA Seal of Acceptance, indicating a diabetes-friendly and podiatric-aware design.