Womens Glycerin 22 Neutral Running Shoe - Plush Neutral Cushion

Our review of the Womens Glycerin 22 Neutral Running Shoe finds it best for runners and everyday walkers who prioritize maximum cushioning and smooth transitions. Built around Brooks' new DNA Tuned midsole, the Glycerin 22 balances a soft, plush heel landing with a responsive forefoot for energetic toe-offs, making it a comfortable option for road runs, gym sessions, or long days on your feet. The shoe's APMA Seal and PDAC A5500 diabetic certification also make it a sensible pick for anyone seeking protective, well-cushioned footwear.

Key Features

• Neutral support: Provides neutral stability with the maximum amount of cushioning for runners who do not need corrective support.
• DNA Tuned cushion: Larger heel cells deliver plush landings while smaller forefoot cells create a responsive toe-off for smoother strides.
• Accommodating fit: A double jacquard knit upper offers flexible, breathable coverage that adapts to the foot and helps reduce pressure points.
• Stable transitions: A broad platform combined with a tuned heel and forefoot stabilizes the foot and smooths heel-to-toe movement.
• Medical endorsements: Certified PDAC A5500 for diabetic use and awarded the APMA Seal of Acceptance for foot health concerns.

Who It's For

The Glycerin 22 is ideal for road runners and active walkers who want premium cushioning without added corrective features; its neutral platform suits those with normal pronation and anyone who values a soft, protective ride. The roomy toe box and compliant upper also make it a good choice for people who need extra space or have sensitive feet, including those seeking diabetic-friendly footwear.

Runners who need strong motion control or serious overpronation correction should look at stability models such as the Glycerin GTS series instead, and minimalist runners who prefer a firmer, low-stack feel will likely find this shoe too plush for their needs.

Pros & Cons

Pros

• Excellent cushioning that lets users walk long distances with reduced joint discomfort.
• Smooth, stable transitions thanks to the broad platform and tuned heel-to-toe design.
• Comfortable, breathable knit upper with an accommodating fit and a roomy toe box.
• Recognized for foot health with APMA acceptance and PDAC A5500 diabetic certification.

Cons

• Sizing has mixed reports; some customers find the fit smaller than expected, so trying on or checking fit advice is recommended.
• The maximal cushioning may feel too soft for runners who prefer a firmer, more responsive race-day shoe.

Specifications

Model	Glycerin 22
Support type	Neutral
Cushioning tech	DNA Tuned midsole
Upper	Double jacquard knit
Certifications	APMA Seal of Acceptance; PDAC A5500 diabetic
Predecessor	Glycerin 21

Our Verdict

The Womens Glycerin 22 is a strong choice for runners and active users who want maximum cushioning, smooth heel-to-toe transitions, and an accommodating fit backed by foot-health certifications. It offers good value as a daily trainer or walking shoe, though those needing stability correction or a firmer ride should consider other options.

Frequently Asked Questions

Are these shoes good for walking long distances?
Yes. The plush DNA Tuned midsole and broad platform make the Glycerin 22 comfortable for extended walking and can reduce knee and hip strain.

Do they provide arch support for overpronation?
No. This is a neutral shoe; runners needing support for overpronation should choose a stability model like the Glycerin GTS.

Do they fit true to size?
Fit can vary; several customers reported the shoe runs small, so trying them on or ordering with the retailer's sizing guidance is advised.