Womens Glycerin 22 Neutral Running Shoe - Plush, Stable Ride

In this review of the Womens Glycerin 22 Neutral Running Shoe the bottom line is clear: this is a premium neutral trainer built for runners and walkers who want maximum cushioning without sacrificing smooth transitions. The shoe stands out because of Brooks DNA Tuned midsole technology that blends larger heel cells with smaller forefoot cells for soft landings and responsive toe-offs, making it ideal for long miles, cross training, or all-day wear. It also carries the APMA Seal of Acceptance and is certified as a PDAC A5500 Diabetic shoe, which adds confidence for runners who need an accommodating, health-minded design.

Key Features

• DNA Tuned Cushion: The midsole combines larger cells in the heel and smaller cells in the forefoot to provide both plush landings and energetic toe-offs for smoother strides.
• Neutral Support: Designed as a neutral shoe, it provides maximum cushioning without corrective elements, suitable for runners who do not need stability features.
• Accommodating Fit: The double jacquard knit upper offers flexible stretch and breathability while maintaining durability for varied activity.
• Smooth, Stable Transitions: A broad platform plus tuned heel and forefoot promote steady heel-to-toe movement and reduced wobble on the road.
• Medical Acceptance: Certified PDAC A5500 and granted the APMA Seal of Acceptance, indicating an accommodating design for foot health concerns.

Who It's For

The Glycerin 22 is best for women who want a plush, highly cushioned neutral trainer for road running, gym sessions, long walks, or daily wear. Runners with knee or hip sensitivity will appreciate the soft heel landings and stable platform that reduce impact and feel supportive over longer distances.

Those who need substantial motion control or corrective arch support should consider a stability model instead, such as the Glycerin GTS line. Also, buyers who require a very precise fit should note that customers report mixed sizing, so trying a pair on or checking return options is wise before committing.

Pros & Cons

Pros

• Excellent cushioning that many users describe as soft and squishy for long-distance comfort.
• Supportive feel for knees and hips thanks to the broad platform and tuned transitions.
• Breathable, flexible upper that accommodates different foot shapes and a roomy toe box.

Cons

• Sizing appears inconsistent in customer reports, with some noting the shoe runs small, so careful size selection is needed.

Specifications

Our Verdict

The Womens Glycerin 22 is a strong pick for runners and active walkers who prioritize maximum cushioning and smooth transitions without added stability hardware. Its DNA Tuned midsole and broad platform deliver a plush but responsive ride, and the accommodating knit upper works well for wider feet or those needing extra comfort. Given the medical certifications and well-executed cushioning, it represents good value for anyone seeking a soft, supportive neutral trainer.

Frequently Asked Questions

Do these shoes suit long runs?
Yes, the soft heel cushioning and tuned forefoot make them comfortable for long road runs and extended walking sessions.

Are they good for wide feet?
The engineered knit upper and roomy toe box provide an accommodating fit that works well for many wider foot shapes.

Should I size up or down?
Customer feedback is mixed on sizing, with some finding them small; try your normal running size first and exchange if they feel tight.