Womens Glycerin 22 Neutral Running Shoe - Plush, Supportive Cushion

Our review of the Womens Glycerin 22 Neutral Running Shoe finds it best suited to runners and walkers who prioritize maximum cushioning without added stability features. The single biggest reason to consider these shoes is the new DNA Tuned cushion, which pairs larger heel cells for soft landings with smaller forefoot cells for livelier toe-offs, delivering a plush yet responsive ride. This version is also a certified PDAC A5500 diabetic shoe and carries the APMA Seal of Acceptance, making it a strong choice for anyone who needs extra foot protection and proven support.

Key Features

• Neutral support: Provides neutral support while delivering the maximum amount of cushioning for road runs and general training.
• DNA Tuned cushion: Larger midsole cells in the heel offer soft landings, while smaller forefoot cells promote energetic toe-offs for smoother transitions.
• Accommodating fit: The double jacquard knit upper stretches where needed for comfort and breathability without feeling overly tight.
• Smooth transitions: A broad platform combined with a tuned heel and forefoot stabilizes the foot and helps heel-to-toe movement feel seamless.
• Medical certifications: Certified PDAC A5500 for diabetic use and awarded the APMA Seal of Acceptance for foot health considerations.

Who It's For

The Glycerin 22 is aimed at neutral runners, walkers, and gym-goers who want maximum cushioning and a soft ride on roads and treadmills. Its roomy toe box and plush midsole make it especially suitable for people who need extra comfort for long-distance walking or who appreciate a protective, cushioned shoe for everyday wear.

Those who need corrective stability or severe overpronation should consider a stability model instead, such as the Glycerin GTS 22, which adds support features. Runners looking for a very lightweight racer or minimal shoe will likely find the Glycerin 22 heavier and more cushioned than they prefer.

Pros & Cons

Pros

• Exceptional cushioning and a soft, squishy sole that reduces impact on knees and hips.
• Accommodating, breathable double jacquard knit upper that fits a variety of foot shapes.
• Certified PDAC A5500 diabetic shoe and APMA-accepted for added foot health confidence.
• Broad platform and tuned geometry produce stable, smooth transitions from heel to toe.

Cons

• Sizing feedback is mixed; some customers report the shoes run smaller than expected, so trying on or sizing up may be necessary.
• Maximum cushioning can feel bulky to runners who prefer firmer, faster shoes.

Specifications

Model	Glycerin 22
Support type	Neutral
Cushion technology	DNA Tuned midsole with dual-size cells
Upper	Double jacquard knit
Certifications	PDAC A5500 diabetic shoe; APMA Seal of Acceptance
Best use	Road running, cross training, walking, gym

Our Verdict

The Womens Glycerin 22 is a top pick for neutral runners and walkers who want maximum cushioning and a protective, comfortable fit. Its DNA Tuned cushion and medical certifications make it a worthwhile value for those prioritizing comfort and foot health, though buyers who need strong corrective support or a firmer ride should look elsewhere.

Frequently Asked Questions

Do these run true to size?
Some customers report the Glycerin 22 runs small, so consider trying them on or ordering a half size up if between sizes.

Are these suitable for diabetic feet?
Yes, this model is certified PDAC A5500 and carries the APMA Seal of Acceptance, indicating it meets standards for diabetic-friendly footwear.

Can I use these for daily gym and cross training?
Yes, the neutral support and plush cushioning make them suitable for road running, gym sessions, and general cross training.