Womens Glycerin 22 Neutral Running Shoe - Soft, Smooth Ride

Our review of the Womens Glycerin 22 Neutral Running Shoe finds it best suited to runners and walkers who prioritize plush cushioning and smooth transitions. The single biggest reason to consider these shoes is the updated DNA Tuned cushion, which blends larger heel cells for a soft landing with smaller forefoot cells for a responsive toe-off, creating a balance of luxurious comfort and energetic gait that shows in everyday road runs, long walks and gym sessions.

Key Features

• Neutral support: Provides neutral guidance with maximum cushioning, making it versatile for road running, cross training and long-distance walking.
• DNA Tuned cushion: Larger heel cells absorb impact while smaller forefoot cells return energy for more responsive toe-offs.
• Certified diabetic fit: Certified PDAC A5500 diabetic shoe construction and the APMA Seal of Acceptance indicate an accommodating, foot-friendly design.
• Accommodating upper: A double jacquard knit upper offers flexibility, breathability and a roomier toe box for comfort on longer outings.
• Stable platform: A broad platform with a tuned heel and forefoot smooths heel-to-toe transitions and aids stable gait mechanics.
• Successor improvements: Builds on the Glycerin 21 with refined cushioning and knit fit for a softer overall feel.

Who It's For

These shoes are ideal for women who want maximum cushioning without extra support structure, such as neutral runners, walkers covering long distances, and gym-goers who value a soft, stable ride. The diabetic shoe certification and APMA acceptance also make them a strong option for anyone needing an accommodating, foot-health mindful shoe.

Runners who need pronounced stability or motion control should consider a support model instead, like a Glycerin GTS variant, and those seeking an ultra-light race shoe will likely find this model heavier and more cushioned than desired.

Pros & Cons

Pros

• Excellent cushioning with a plush heel and responsive forefoot for comfortable long miles.
• Accommodating knit upper and roomy toe box improve comfort for wider feet or foot conditions.
• Certified PDAC A5500 and APMA Seal add confidence for users who need foot-friendly footwear.
• Broad platform and tuned transitions promote a smooth, stable stride.

Cons

• Sizing reports vary and some customers find they run small, so trying on before committing is advisable.
• Maximal cushioning may feel heavy for runners who prefer a minimal, fast-feeling shoe.

Specifications

Model	Glycerin 22 (Womens)
Support	Neutral
Cushioning Technology	DNA Tuned midsole
Upper	Double jacquard knit, breathable
Health Certifications	PDAC A5500 certified; APMA Seal of Acceptance
Intended use	Road running, cross training, walking, gym

Our Verdict

The Womens Glycerin 22 is a smart buy for neutral runners and walkers who want maximum, foot-friendly cushioning and smooth heel-to-toe transitions. Its DNA Tuned cushion and accommodating knit upper make it good value for anyone prioritizing comfort and joint support over lightweight speed.

Frequently Asked Questions

Are these shoes good for long walks?
Yes, the plush cushioning and roomy toe box make them comfortable for extended walking and standing sessions.

Do they provide support for overpronation?
No, this model is neutral; choose the Glycerin GTS if you need added support for overpronation.

Do they run true to size?
Customer feedback is mixed on sizing and some report they run small, so try them on or check the retailer's fit guidance before ordering.