Women's Glycerin GTS 22 Supportive Road Running Shoe

Our review of the Glycerin GTS 22 finds it best suited to runners who want plush cushioning paired with corrective support. The shoe blends Brooks' latest DNA Tuned midsole technology and GuideRails holistic support to deliver soft landings and controlled toe-offs while limiting excess motion. For anyone tackling road miles, gym sessions, or recovery runs and who values stability without a rigid feel, this model is an easy recommendation for comfort and restraint; customers most frequently praise the cushioning and overall support.

Key Features

• GuideRails support: The holistic GuideRails system keeps excess motion in check to help stabilize the foot through long road runs and varied workouts.
• DNA Tuned cushion: Dual-size midsole cells give a plush heel landing and a more responsive forefoot for smoother heel-to-toe transitions.
• Accommodating fit: The double jacquard knit upper stretches to adapt to the foot while maintaining breathability and durability.
• Stable platform: A broad base stabilizes the foot and, together with tuned heel and forefoot geometry, smooths transitions between strides.
• Certified diabetic option: This model is PDAC A5500 certified, indicating suitability for wearers needing diabetic shoe accommodations.

Who It's For

The Glycerin GTS 22 is geared toward women who want a combination of plush cushioning and added support - road runners, walkers, and gym goers who benefit from stability features without sacrificing softness. It is especially useful for those who appreciate a forgiving heel and a responsive toe-off for steady, comfortable miles.

Runners who prefer a very wide toe box or a minimalist, low-profile shoe should look elsewhere; some users report a narrower toe area. Also, if you need a super-light racing flat, the Glycerin GTS 22 is heavier and designed more for daily training and support than speed-work.

Pros & Cons

Pros

• Exceptional cushioning with a soft heel and energetic forefoot push for comfortable long runs.
• GuideRails provide tangible stability and help control excess motion without feeling restrictive.
• Upper knit fabric delivers an accommodating, breathable fit that balances comfort and durability.

Cons

• Some wearers find the toe box a bit narrow compared with other cushioned trainers.
• Not intended as a lightweight race shoe; it favors daily comfort and support over minimalism.

Specifications

Model	Glycerin GTS 22
Support system	GuideRails holistic support
Midsole technology	DNA Tuned with dual-size cells
Upper	Double jacquard knit
Recommended use	Road running, cross training, gym
Predecessor	Glycerin GTS 21
Certification	PDAC A5500 diabetic shoe certified

Our Verdict

The Glycerin GTS 22 is a solid choice for women seeking plush daily cushioning combined with reliable stability. It represents good value for runners who prioritize comfort, supportive control and breathable fit, though those needing a very roomy toe box or a race-day minimal shoe should consider alternatives.

Frequently Asked Questions

Do these run true to size?
Fit varies; many find the length true to size but a portion of wearers report the toe box feels slightly narrow compared with other trainers.

Can I use these for gym workouts as well as running?
Yes, the GuideRails support and cushioned DNA Tuned midsole make them suitable for road running, cross training and general gym use.

Are these suitable for diabetic feet?
Yes, this model is PDAC A5500 certified, indicating it meets standards for diabetic shoe accommodations.