Womens Glycerin GTS 22 Supportive Running Shoe - Cushioned GuideRails

In this review of the Womens Glycerin GTS 22 Supportive Running Shoe, the bottom line is straightforward: this shoe is for runners and active women who want plush cushioning with built-in stability. The standout reason to buy is the combination of Brooks DNA Tuned midsole cushioning and the GuideRails support system, which together deliver soft landings and controlled motion through toe-off. Reviewers repeatedly praise the comfort and cushioning as life-changing, making these shoes an easy choice for road running, gym sessions, or everyday wear when protection against excess motion matters.

Key Features

• GuideRails support: Keeps excess motion at bay so knees and hips track more naturally during runs and cross training.
• DNA Tuned cushion: Larger heel cells and smaller forefoot cells provide a soft landing and responsive toe-offs for smoother transitions.
• Accommodating fit: The double jacquard knit upper flexes with the foot for breathable comfort without feeling overly restrictive.
• Stable platform: A broad base stabilizes the foot through heel-to-toe movement and reduces wobble on road surfaces.
• Diabetic friendly: Certified PDAC A5500, making this model suitable for users who need diabetic shoe accommodations.

Who It's For

The Glycerin GTS 22 is ideal for women who seek maximal cushioning plus guidance for natural foot motion. Road runners who value plush landings but need extra support around the midline will appreciate the GuideRails system, and gym-goers or walkers who want comfortable, stable shoes will find them reliable.

Those who need a very wide toe box or prefer a minimal, highly responsive racing shoe should look elsewhere; some users report the toe box can feel narrow. If you want the same cushion without the added GuideRails, the non-GTS Glycerin 22 might be a better fit.

Pros & Cons

Pros

• Exceptionally comfortable cushioning that many customers describe as transformative for long runs and daily wear.
• GuideRails support provides noticeable stabilization without feeling intrusive.
• Durable, breathable knit upper that adapts to foot shape for a secure fit.

Cons

• Some wearers find the toe box narrower than expected, so those with wide forefeet may need to size up or try a different model.

Specifications

Our Verdict

The Womens Glycerin GTS 22 is a strong pick for runners and active women who prioritize plush cushioning plus integrated support. Its DNA Tuned midsole and GuideRails system create smooth, stable transitions and long-wear comfort, making it good value for anyone who needs extra motion control without sacrificing softness.

Frequently Asked Questions

Do these run true to size?
Customers disagree; many find normal sizing fine but those with wider toes sometimes recommend trying a half size up.

Are these suitable for diabetic feet?
Yes, this model is PDAC A5500 certified, indicating it meets standards for diabetic shoe accommodations.

Is the GTS 22 very different from the Glycerin 22?
The main difference is GuideRails support in the GTS 22, which adds stabilizing control compared with the non-GTS Glycerin 22.