Womens Glycerin GTS 22 Supportive Running Shoe - GuideRails Cushion

In this review the Womens Glycerin GTS 22 is presented as a support-focused daily trainer for women who want plush cushioning without sacrificing stability. The single biggest reason to buy is the blend of Brooks DNA Tuned midsole cushion and GuideRails support that delivers soft landings and guided, stable transitions; reviewers highlight reduced foot, hip and back pain when switching to these shoes. Fit impressions are mixed, so readers should weigh toe box space and cushioning preference before committing to a purchase.

Key Features

• DNA Tuned Cushion: Larger midsole cells in the heel and smaller forefoot cells create soft, plush landings with responsive toe-offs for smoother runs.
• GuideRails Support: Holistic support keeps excess motion in check, helping stabilise the knee and reduce strain during long runs or cross training.
• Accommodating Fit: The double jacquard knit upper offers flexibility and breathability while adapting to different foot shapes for extended comfort.
• Stable Platform: A broad base plus tuned heel-to-toe geometry promotes smooth, stable transitions from heel strike to toe-off.
• Certified Diabetic Option: The Glycerin GTS 22 is a PDAC A5500 certified diabetic shoe, making it a suitable choice for users who need that designation.

Who It's For

The Glycerin GTS 22 is best for women who run on roads, use the gym, or do cross training and want a cushioned shoe with added motion control from a supportive system. Runners who have had foot, hip, or back discomfort and need a shoe that prioritises stability alongside plush cushioning will likely benefit most.

Those seeking a very narrow racing fit or a minimal, highly responsive feel should look elsewhere, as this shoe leans toward a softer, more protective ride. Also, shoppers who are extremely particular about toe box width should try these on first because customers report mixed sizing and toe space impressions.

Pros & Cons

Pros

• Comfortable, plush cushioning that helps reduce foot and related joint pain for many wearers.
• GuideRails system provides noticeable support and helps stabilise excess motion on runs.
• Breathable, flexible double jacquard knit upper that adapts to the foot.
• Certified PDAC A5500 diabetic shoe, expanding suitability for those with specific foot care needs.

Cons

• Fit and toe box sizing receive mixed feedback, so some may find the forefoot too narrow or roomy depending on their foot shape.
• Cushion feel is debated by customers; runners preferring a firmer, more responsive ride may find this model too soft.

Specifications

Our Verdict

The Glycerin GTS 22 is a strong choice for women who prioritize cushioning and stability in one trainer; its DNA Tuned midsole and GuideRails support make it especially useful for those recovering from or prone to foot and joint discomfort. It represents good value for runners seeking a comfortable daily trainer with certified diabetic options, provided they verify fit and cushioning preference before buying.

Frequently Asked Questions

Are these shoes good for walkers and light gym use?
Yes, the combination of plush cushion and GuideRails support makes them well suited to road walking and gym sessions as well as running.

Do these run true to size?
Customer feedback is mixed; some report a roomy toe area while others find the toe box narrow, so trying them on is recommended.

Is this model different from the previous generation?
The GTS 22 follows the GTS 21 with the same support focus but features updated DNA Tuned midsole tuning and a new double jacquard knit upper.