Womens Glycerin GTS 22 Supportive Running Shoe - Plush Cushioning

Our review of the Womens Glycerin GTS 22 finds it best suited to runners and gym goers who prioritize plush cushioning and guided stability. The single biggest reason to consider these shoes is the combination of DNA Tuned cushioning and the GuideRails support, which deliver soft landings and controlled motion for longer runs or daily wear. Fit and toe-box shape divide opinion among buyers, so while many praise the comfort, some should try them on before committing.

Key Features

• GuideRails support: Keeps excess motion in check to help stabilize the foot and reduce strain on the knees during road runs or cross training.
• DNA Tuned cushion: Larger heel cells create plush landings while smaller forefoot cells provide responsive toe-offs for smoother transitions.
• Accommodating fit: The double jacquard knit upper offers durable breathability and adapts to foot shape for everyday comfort.
• Smooth transitions: A broad platform with a tuned heel and forefoot smooths the heel-to-toe roll for stable road running.
• Certified diabetic option: The model is PDAC A5500 certified, making it suitable for users who need a medically indicated shoe.

Who It's For

The Glycerin GTS 22 is ideal for women who want a supportive, cushioned road running shoe that also works for gym sessions and everyday wear; the GuideRails system makes it a good pick for runners who overpronate or want extra lateral control. It also suits walkers and anyone who benefits from a plush heel landing and energetic toe-off when transitioning to a faster pace.

Runners who need an especially wide toe box or who always buy the same narrow-fitting model may want to try these on first, as some customers reported a tighter toe area. If you prefer very minimalist, low-profile shoes, this max-cushion supportive trainer is not the best match.

Pros & Cons

Pros

• Excellent comfort and life-changing cushioning for long runs and long days on your feet.
• Reliable support from GuideRails keeps excess motion under control without feeling overly rigid.
• Durable, breathable knit upper provides an accommodating fit and modern styling.
• PDAC A5500 certification makes it a practical option for those needing diabetic footwear.

Cons

• Some users find the toe box narrower than expected, so sizing and fit can be inconsistent.
• Price-conscious buyers are split on value, with a few feeling the cost is high for their needs.

Specifications

Model	Glycerin GTS 22
Support system	GuideRails holistic support
Cushion technology	DNA Tuned midsole with varied cell sizes
Upper	Double jacquard knit
Ideal use	Road running, cross training, gym
Certification	PDAC A5500 diabetic shoe

Our Verdict

The Womens Glycerin GTS 22 is worth buying for women who want plush, stable rides and built-in motion control; the blend of cushioning and GuideRails support improves comfort on long runs and daily wear. Try them on for fit, especially if you need a roomy toe box, but for supportive road runners this model represents solid value for the stability and comfort it delivers.

Frequently Asked Questions

Are these shoes good for overpronation?
Yes, the GuideRails system is designed to control excess motion and help stabilize the foot for overpronators.

Do they run true to size?
Customer reports vary; many find the fit true, but some note a narrower toe box so trying them on is recommended.

Can I use them for gym workouts?
Yes, they are suitable for cross training and gym use as well as road running thanks to the stable platform and cushioning.